Experiment 68754
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Crataegus oxyacantha (ROSACEAE) |
| Citation | RIETBROCK,N: HAMEL,M: HEMPEL,B: MITROVIC,Y: SCHMIDT,T: WOLF,GK:. (2001). EFFICACY OF A STARDARDIZED EXTRACT OF FRESH CRATAEGUS BERRIES ON EXERCISE TOLERANCE AND QUALITY OF LIFE IN PATIENTS WITH CONGESTIVE HEART FAILURE (NYHA II).. 51(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS TRIAL THE EFFICACY OF A STANDARDIZED EXT. OF FRESH CRATAEGUS BERRIES ON EXERCISE TOLERANCE AND QUALITY OF LIFE WAS STUDIED IN 8 PATIENTS. IN A THREE-MONTH PLACEBO-CONTROLLED, RANDOMIZED, DOUBLE-BLIND TRIAL THESE PATIENTS WERE TREATED WITH ROB 10 (3 X 25 DROPS DAILY). TOTAL EXERCISE TIME IN BICYCLE ERGOMETRY WAS DEFINED AS PRIMARY EFFICACY VARIABLE, WHILE QUALITY OF LIFE (MINNESOTA QUESTIONNAIRE), DYSPNEA-FATIGUE INDEX AND THE ASSESSMENT OF DYSPNEA BY THE PATIENT ON A VISUAL ANALOGOUS SCALE WERE CHOSEN AS SECONDARY PARAMETERS. INVESTIGATIONS WERE PERFORMED AFTER A TWO WEEK PLACEBO RUN-IN PERIOD AS WELL AS 6 AND 12 WK AFTER THE ONSET OF THE STUDY. TREATMENT WITH ROB 10 LED TO A INCREASE ON EXERCISE TIME OF 38.9 S VS. PLACEBO (95% CONFIDENCE INTERVAL 5.7-72.1 S). QUALITY OF LIFE IMPROVED ACCORDINGLY IN FAVOR OF ROB 10. IN THE MINNESOTA QUESTIONNAIRE, THE TOTAL SCORE FELL BY 31% (30.6 VS. 44.1) UNDER ROB 10 VS. 18% (34.6 VS. 42.4) UNDER PLACEBO. ACCORDING TO FINDINGS OF THE ASSESSMENT OF DYSPNEA BY THE PATIENT, DYSPNEA DECREASED BY 11% (50.5 VS. 56.6 MM) VS. 4% (54.8 VS. 57.3 MM) UNDER PLACEBO. THE PRESENT STUDY PROVES THE EFFICACY AND SAFETY OF A STANDARIZED EXT. OF FRESH CRATAEGUS BERRIES (ROB 10) IN PATIENTS WITH CONGESTIVE HEART FAILURE (NYHA II) REGARDING THE PARAMETERS EVALUATED. |
| Dose amount | 4.5 ML |
| Number | 2 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ETOH(60%)EXT |
| Gender | GIVEN TO BOTH SEXES |