Experiment 68761
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Ginkgo biloba (GINKGOACEAE) |
| Citation | HEMMETER,U: ANNEN,B: BISCHOF,R: BRUDERLIN,U: HATZINGER,M: ROSE,U: HOLSBOER TRACHSLER,E:. (2001). POLYSOMNOGRAPHIC EFFECTS OF ADJUVANT GINKGO BILOBA THERAPY IN PATIENTS WITH MAJOR DEPRESSION MEDICATED WITH TRIMIPRAMINE.. 34(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | AN OPEN NON-RANDOMIZED PILOT STUDY HAS BEEN CONDUCTED TO INVESTIGATE THE EFFECTS OF GINKGO BILOBA EXTRACT (EGB LI 1370) ON COGNITIVE PERFORMANCE AND SLEEP REGULATION IN DEPRESSED INPATIENTS. 16 PATIENTS WERE TREATED WITH A TRIMIPRAMINE (T)-MONOTHERAPY (200MG) FOR SIX WEEKS. IN EIGHT OF THE 16 PATIENTS. AN ADJUNCT EGB THERAPY (240MG/D) WAS APPLIED FOR FOUR WEEKS AFTER A BASELINE WEEK, THE OTHER EIGHT PATIENTS REMAINED ON TRIMIPRAMINE MONOTHERAPY (200MG) DURING THE ENTIRE STUDY. POLYSOMNOGRAPHY. COGNITIVE PSYCHOMOTOR PERFORMANCE AND PSYCHOPATHOLOGY WERE ASSESSED AT BASELINE, AFTER SHORT-TERM AND LONG-TERM ADJUNCT EGB TREATMENT, AND AFTER ONE WEEK OF GINKGO DISCONTINUATION (AT THE RESPECTIVE EVALUATION TIMES IN THE EIGHT PATIENTS ON T-MONOTHERAPY). THIS REPORT FOCUSES ON THE RESULTS OF EGB ON SLEEP EEG PATTERN. EGB SIGNIFICANTILY IMPROVED SLEEP ATEEERN BY AN INCREASE OF SLEEP STAGE 1 AND REM-DENSITY WERE REDUCED, WHILE STAGE 2 WAS INCREASED. NON-REM SLEEP, PREDOMINANTLY SLOW WAVE SLEEP IN THE FIRST SLLEP CYCLE, WAS SIGNIFICANTLY ENHANCED COMPARED TO TRIMIPRAMINE MONOTHERAPY. DISCONTINUATION OF EGB REVERSED MOST OF THESE EFFECTS. A COMMERCIAL PRODUCT, EGB-761, WAS USED. |
| Dose amount | 240.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ACETONE EXT |
| Gender | GIVEN TO BOTH SEXES |