Experiment 68814
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | KLIER,CM: SCHAFER,MR: SCHMID-SIEQEL,B: LENZ,G: MANNEL,M:. (2002). ST. JOHN'S WORT (HYPERICUM PERFORATUM) - IS IT SAFE DURING BREASTFEEDING?. 35(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | A MOTHER WITH POST-NATAL DEPRESSION WAS ADMITTED AT OUR SERVICE. HER PHARMACIST HAD RECOMMENDED TAKING A ST. JOHN'S WORT PREPARATION THREE TIMES A DAY (JARSIO 300. LICHTWER PHARMA AF. BERLIN, GERMANY). FOUR BREAST MILK SAMPLES (FORE AND HIND MILK) DURING AN 18 HOUR PERIOD WERE ANALYZED TO MEASURE CONCENTRATION OF HYPERICIN AND HYPERFORIN. ONLY HYPERFORIN IS EXCRETED INTO BREAST MILK AT A LOW LEVEL, HYPERFORIN AND HYPERICIN (TWO MAJOR ACTIVE COMPONENTS) WERE BELOW THE LOWER LIMIT OF QUANTIFICATION (BLQ BELOW LOWER LIMIT OF QUANTIFICATION, LQ HYPERICIN 0.20 NG/ML, LQ HYPERFORIN 0.50 MG/ML) IN THIS INFANT'S PLASMA. NO SIDE EFFECTS WERE SEEN IN THE MOTHER OR INFANT. BEFORE RECOMMENDING ST. JOHN'S WORT FOR THE TREATMENT OF DEPRESSION TO WOMEN WHO BREASTFEED, LONG-TERM STUDIES OF OUTCOME IN INFANTS ARE NEEDED. |
| Dose amount | 900.0 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | FEMALE |