Experiment 68819
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | RECTAL |
| Organism | Serenoa repens (ARECACEAE) |
| Citation | BERNARDI DI VALSERRA,MD: TRIPODI,AS:. (1994). RECTAL BIOAVAILABILITY AND PHARMACOKINETICS IN HEALTHY VOLUNTEERS OF SERENOA REPENS. NEW FORMULATION.. 46() |
| Amount utilized | |
| Compound isolated | |
| Disease | THE BIOAVAILABILITY AND PHARMACOKINETIC PROFILE OF A NEW DEVELOPED 640 MG RECTAL SERENOA REPENS EXTRACT PREPARATION WERE DETERMINED IN 12 HEALTHY MALE VOLUNTEERS. DRUG WAS ADMINISTERED AT DOSE OF 640 MG, BLOOD SAMPLES WERE COLLECTED AT 0.5-1.5-2-3-4-6-8 AND 10 HOURS AFTER, AND PLASMA CONCENTRATIONS OF SERENOA REPENS 2ND COMPONETS WERE QUANTIFIED BY A HPLC-METHOD. MEAN MAXIMUM CONCENTRATION OF 2ND COMPONENT IN PLASMA OF NEARLY 2.60 UG/ML ABOUT 3 HOURS AFTER DRUG INTAKE WITH MWAN VALUE FOR THE AREA UNDER THE CURVE AUC OF 10UG*H/ML WERE OBSERRVED. THE BIOAVAILABILITY AND PHARMACOKINETIC PROFILE OF A 640 MG RECTAL SERENOA REPENS ADMINISTRATION, ONLY T(MAX) OCCURRED ABOUT 1 H LATER AND SERENOA REPENS 2ND COMPONENT PLASMA CONCENTRATION 8 HOURS AFTER DRUG ADMINISTRATION WAS STILL QUANTIFIED. THE DRUG TOLERABILITY WAS GOOD AND NO ADVERSE EFFECT WERE OBSERVED. |
| Dose amount | 640.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | FIXED OIL |
| Gender | MALE |