Experiment 68825
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IM |
| Organism | Echinacea purpurea (ASTERACEAE) |
| Citation | LERSCH,C: ZEUNER,M: BAUER,A: SIEBENROCK,K: HART,R: WAGNER,F: FINK,U: DANCYGIER,H: CLASSEN,M:. (1990). STIMUALTION OF THE IMMUNE RESPONSE IN OUTPATIENTS WITH HEPATOCELLULAR CARCINOMAS BY LOW DOSES OF CYCLOPHOSPHAMIDE (LDCY). ECHINACEAE PURPUREA EXTRACTS (ECHINACIN) AND THYMOSTIMULIN.. 60(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | OUTPATIENTS WITH INOPERABLE FAR ADVANCED HEPATO-CELLULAR CARCINOMAS (N=5) WERE TREATED WITH LDCY - 300 MG/M2 I.V. EVERY 28 DAYS , ECHINACIN - 60 MG/M2 I.M., AND THYMOSTIMULIN - 30 MG/M2 I.M., DAY 3 -10 AFTER LDCY, THEN TWICE A WEEK. THERAPY WAS WELL TOLERATED BY ALL PATIENTS. THEIR KARNOFSKY' INDEX INCREASED FOR 10% IN THE MEAN. A STABLE DISEASE FOR MORE THAN 8 WEEKS WAS DOCUMENTED BY ABDOMICAL ULTRASONOGRAPHY IN ONE PATIENT. SERUM LEVELS OF ALPHA-FETOPROTEIN (AFP), CARCINOEMBRYONIC ANTIGEN (CEA) AND TISSURE POLYPEPTIDE NTIGEN (TPA) DID NOT INCREASE IN 2 PATIENTS. MEDIAN SURVIVAL TIME WAS 2.5 MONTHS. ONE PATIENT IS STILL ALIVE AFTER 8 MONTHS. ABSOLUTE NUMBERS OF CD 8+ CELLS SIGNIFICANTLY (P <0.02) DECREASED FOR 7% 1 DAY AFTER LDCY, WHEREAS CD4+ CELLS INCREASED )P<0.02) FROM DAY 1-7. NUMBERS OF NATURAL KILLER (NK -) CELLS INCREASED FOR 17% (P<0.05), THEIR ACTIVITY FOR 90% (P<0.05). ACTIVITIES OF PERIPHERAL POLYMORPHS (P<0.05) INCREASED FOR 27% AND LYMPHOKINE ACTIVATED KILLER (LAK -) CELLS FOR 180% (P<0.05). |
| Dose amount | 60.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | CUBIC METER |
| Dose expression | DOSE |
| Extract | H2O EXT |
| Gender | GIVEN TO BOTH SEXES |