Experiment 68841
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Petasites hybridus (ASTERACEAE) |
| Citation | THOMET,OAR: SCHAPOWAL,A: HEINISCH,VWM: WIESMANN,UN: SIMON,HU:. (2002). ANTI-INFLAMMATORY ACTIVITY OF AN EXTRACT OF PETASITES HYBRIDUS IN ALLERGIC RHINITIS.. 2(7) |
| Amount utilized | |
| Compound isolated | |
| Disease | SIX PATIENTS SUFFERING FROM ALLERGIC RHINITIS RECEIVED THREE TIMES A DAY TWO TABLETS OF ZE339 STANDARDIZED TO 8 MG PETASINS WITHIN A TIME NASAL SYMPTOMS. NASAL RESISTANCE, WHICH WAS MEASURED BY RHINOMANOMENTRY, GRADUALLY DECREASED AS A CONSEQUENCE OF ZE339 TREATMENT REACHING NORMAL LEVELS AFTER 5 DAYS. LEVELS OF INFLAMMATORY MEDIATORS IN NASAL FLUIDS AND SERUM WERE MEASURED 90 MIN AFTER DRUG ADMINISTRATION EVERY DAY IN THE MORNING. AFTER 5 DAYS OF TREATMENT, A SIGNIFICANT REDUCTION OF HISTAMINE (FROM 153.7+/-32.1 TO 53.0+/-8.4 PG/ML) AND LT LEVELS (LTB4: FROM 313.1+/-46.5 TO 180.6+/-32.2 PG/ML; CYSTEIN-LT: FROM 137.0+/-42.2 TO 70.1+/-16.5 PG/ML) COULD BE OBSERVED. MOREOVER, QUALITY-OF-LIFE SCORES SIGNIFICANTLY IMPROVED. THESE RESULTS SUGGEST THAT ZE339 IS EFFECTIVE IN TREATING ALLERGIC RHINITIS PATIENTS BY DECREASING LEVELS OF NASAL INFLAMMATORY MEDIATORS. |
| Dose amount | 56.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |
| Gender | GIVEN TO BOTH SEXES |