Experiment 68858
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Andrographis paniculata (ACANTHACEAE) |
| Citation | PANOSSIAN,A: HOVHANNISYAN,A: MAMIKONIAN,G: ABRAHAMIAN,H: GOUKASOVA,G: GABRIELIAN,E: WIKMAN,G: WAGNER,H:. (2000). PHARMACOKINETIC ANDROGRAPHOLIDE FROM ANDROGRAPHIS PANICULATA EXTRACT SHA-10 AND ANDROGRAPHIS FIXED COMBINATION KAN JANG IN RATS AND HUMANS.. 7(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | ANDROGRAPHOLIDE WAS QUICKLY AND ALMOST COMPLETELY ABSORBED INTO THE BLOOD FOLLOWING THE ORAL ADMINISTRATION OF APE AT A DOSE OF 20 MG/KG IN RATS. ITS BIOAVAILABILITY HOWEVER DECREASED FOURFOLD WHEN A 10 TIMES HIGHER DOSE WAS USED. SINCE A LARGE PART (55%) OF AND IS BOUND TO PLASMA PROTEINS AND ONLY A LIMITED AMOUNT CAN ENTER THE CELLS, THE PHARMACOKINETICS OF AND IS WELL DESCRIBED BY A ONE-COMPARTMENT MODEL. |
| Dose amount | 20.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |