Experiment 68860

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismEmpty organism
CitationKOVACS,EMR: WESTERTERP-PLANTENGA,MS: DE VRIES,M: BROUNS,F: SARIS,WHM:. (2001). EFFECTS OF 2-WEEK INGESTION OF (-)-HYDROXYCITRATE AND (-)-HYDOXYCITRATE COMBINED WITH MEDIUM-CHAIN TRIGLYCERIDES ON SATIETY AND FOOD INTAKE.. 74(4/5)
Amount utilized
Compound isolated
DiseaseTHE AIM OF THIS STUDY WAS TO ASSESS THE EFFECTS OF 2 WEEKS OF SUPPLEMENTS WITH (-)-HYDROXYCITATE(HCA) AND HCA COMBINED WITH MEDIUM-CHAIN TRIGLYCERIDES(MCT) ON SATIETY AND ENERGY INTAKE. THIS EXPERIMENTAL DESIGN CONSISTED OF THREE INTERVENTION PERIODS OF 2 WEEKS SEPARATED BY WASHOUT PERIODS OF 2 OR 6 WEEKS IN A DOUBLE-BLIND, PLACEBO-CONTROLLED, RANDOMIZED, AND CROSSOVER DESIGN. SEVEN MALE AND 14 FEMALE NORMAL TO MODERATELY OBESE SUBJECT. PARTICIPATED IN THIS STUDY. SUBJECTS CONSUMED THREE SELF-SELECTED MEALS AND FOUR ISOENERGETIC SNACKS DAILY WITH EITHER NO SUPPLEMENTATION (PLA),WITH 500 MG HCA (HCA), OR 500 MG HCA AND 3 G MCT (HCA+MCT). EACH INTERVENTION PERIOD ENDED WITH A TEST DAY, CONSISTING OF A STANDARDIZED BREAKFAST AND A LIBITUM A LUNCH AND A DINNER. THERE WAS SIGNIFICANT BODY WEIGHT (BW) LOSS DURING THE 2 WEEKS OF INTERVENTION (PLA, 0.5+0.3 KG, P<.05; HCA, -0.4+0.2 KG, P<.05; HCA + MCT, -0.7+0.2 KG, P<.01), BUT THIS REDUCTION WAS DIFFERENT BETWEEN TREATMENTS. TWENTY-FOUR-HOUR ENERGY INTAKE (PLA, 8.1+0.3 MJ; HCA, 8.3_0.3 MJ; HCA+MCT, 8.4+0.3 MJ) AND THE AREA UNDER THE CURVE OF THE APPETITE-RELATED PARAMETERS DURING THE TEST DAY WERE SIMILAR FOR ALL TREATMENTS. TWO WEEKS FOR SUPPLEMENTATION WITH HCA AND HCA COMBINED WITH MCT DID NOT RESULT IN INCREASED SATIETY OR DECREASED ENERGY INTAKE COMPARED TO PLACEBO IN SUBJECTS LOSING BW.
Dose amount500.0 MG
Number1
Qualitative resultINACTIVE
AnimalHUMAN ADULT
Per unitDAY
Dose expressionDOSE
GenderGIVEN TO BOTH SEXES