Experiment 68867
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | JOHNE,A: SCHMIDER,J: BROCKMOLER,J: STADELMANN,AM: STORMER,E: BAUER,S: SCHOLLER,G: LANGHEINRICH,M: ROOTS,I:. (2002). DECREASED PLASMA LEVELS OF AMITRIPTYLINE AND ITS METABOLITES ON COMEDICATION WITH AN EXTRACT FROM ST. JOHN'S WORT (HYPERICUM PERFORATUM).. 22(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | TWELVE PATIENTS WERE ADMINISTERED HYPERICUM EXTRACT IN CONJUCTION WITH AMITRIPTYLINE (75 MG 2X DAILY). MULTIPLE DOSE CO-MEDICATION FOR 14 DAYS RESULTED IN A STATISTICALLY SIGNIFICANT DECREASE IN THE AREA UNDER THE CURVE OF AMITRIPTYLINE (BY 22%) WAS OBSERVED. |
| Dose amount | 900.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | ML |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |