Experiment 68954
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | TRINH,NH: HOBLYN,J: MOHANTY,S: YAFFE,K:. (2003). EFFICACY OF CHOLINESTERASE INHIBITORS IN THE TREATMENT OF NEUROPSYCHIATRIC SYMPTOMS AND FUNCTIONAL IMPAIRMENT IN ALZHEIMER DISEASE.. 289() |
| Amount utilized | |
| Compound isolated | |
| Disease | TO CONDUCT A SYSTEMATIC REVIEW AND META-ANALYSIS TO QUANTIFY THE EFFICACY OF CHOLINESTERASE INHIBITORS FOR NEUROPSYCHIATRIC AND FUNCTIONAL COUTCOMES IN PATIENTS WITH MILD TO MODERATE. AD. INCLUDED 29 PARALLEL-GROUP OR CROSSOVER RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIALS OF OUTPATIENTS WHO WERE DIAGNOSED AS HAVING MILD TO MODERATE PROBABLE AD AND WERE TREATED FOR AT LEAST 1 MONTH WITH A CHOLINESTERASE INHIBITOR. SIXTEEN TRIALS INCLUDED NEUROPSYCHIATRIC AND 18 INCLUDED FUNCTIONAL MEASURE. THESE RESULTS INDICATE THAT CHOLINESTERASE INHIBITORS HAVE MODEST BENEFICIAL IMPACT ON NEUROPSYCHIATRIC AND FUNCTIONAL OUTCOMES FOR PATIENTS WITH AD. FUTURE RESEARCH SHOULD FOCUS ON HOW SUCH IMPROVEMENTS TRANSLATE INTO LONG-TERM OUTCOMES SUCH AS PATIENT QUALITY OF LIFE, INSTITUTIONALIZATION, AND CAREGIVER BURDEN. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |