Experiment 68957
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | MATHIJSSEN,RHJ: VERWEIJ,J: DE BRUIJN,P: LOOS,WJ: SPARREBOOM,A:. (2002). EFFECTS OF ST.JOHN'S WORT ON IRINOTECAN METABOLISM.. 94(16) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS STUDY, THE EFFECT OF SJW ON THE METABOLISM OF IRINOTECAN, A PRO-DRUG OF SN-38 AND A KNOWN SUBSTRATE FOR CYP3A4. FIVE CANCER PATIENTS WERE TREATED WITH IRINOTECAN (350MG/M-2, INTRAVENOUSLY) IN THE PRESENCE AND ABSENCE OF SJW (900MG DAILY, ORALLY FOR 18 DAYS) IN AN UNBLINDED, RANDOMIZED CROSSOVER STUDY DESIGN, THE PLASMA LEVELS OF THE ACTIVE METABOLITE SN-38 DECREASED BY 42% FOLLOWING SJW COTREATMENT. CONSEQUENTLY, THE DEGREE OF MYELOSUPPRESSION WAS SUBSTANTIALLY WORSE IN THE ABSENCE OF SJW. THESE FINDINGS INDICATE THAT PATIENTS ON IRINOTECAN TREATMENT SHOULD REFRAIN FORM TAKING SJW BECAUSE PLASMA LEVELS OF SN-38 WERE DRAMATICALLY REDUCED, WHICH MAY HAVE A DELETERIOUS IMPACT ON TREATMENT OUTCOME. |
| Dose amount | 900.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |