Experiment 68977
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Trifolium pratense (FABACEAE) |
| Citation | CLIFTON BLIGH,PB: BABER,RJ: FULCHER,GR: NERY,ML: MORTETON,T:. (2001). THE EFFECT OF ISOFLAVONES EXTRACTED FROM RED CLOVER (RIMOSTIL) ON LIPID AND BONE METABOLISM.. 8(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | A STUDY TO EVALUATE THE EFFECTS OF VARYING DOSES OF PHYTOESTROGENS ON LIPID AND BONE METABOLISM IN POSTMENOPAUSAL WOMEN. A NOVEL RED CLOVER ISOFLAVONE PREPARATION (RIMOSTIL) CONTAINING GENISTEIN, DAIDZEIN, FORMONONETIN, AND BIOCHANIN WAS ADMINISTERED TO 46 POSTMENOPAUSAL IN A DOUBLE BLIND PROTOCOL AFTER A SINGLE-BLIND PLACEBO PHASE AND FOLLOWED BY A SINGLE-BLIND WASHOUT PHASE. PATIENTS WERE RANDOMIZED TO RECEIVE EITHER 28.5 MG, 57 MG, OR 85.5 MG OF PHYTOESTROGENS DAILY FOR A 6-MONTH PERIOD. AT 6 MONTHS, THE SERUM HIGH-DENSITY LIPOPROTEIN CHOLESTEROL HAD RISEN SIGNIFICANTLY BY 15.7-28.6% WITH DIFFERENT DOSES ALTHOUGH THE MAGNITUDE OF THE RESPONSE WAS INDEPENDENT OF THE DOSE USED. THE SERUM APOLIPOPROTEIN B FELL SIGNIFICANTLY BY 11.5-17.0% WITH DIFFERENT DOSES AND THE MAGNITUDE OF THE RESPONSE WAS INDEPENDENT OF THE DOSE USED. THE BONE MINERAL DENSITY OF THE PROXIMAL RADIUS AND ULNA ROSE SIGNIFICANTLY BY 4.1% OVER 6 MONTHS WITH 57 MG/DAY AND BY 3.0% WITH 85.5 MG/DAY OF ISOFLAVONES.THE RESPONSE WITH 28.5 MG/DAY OF ISOFLAVONES WAS NOT SIGNIFICANT. THERE WAS NO SIGNFIFICANT INCREASE IN ENDOMETRIAL THICKNESS WITH ANY OF THE DOSES OF ISOFLAVONE USED. |
| Dose amount | 5.0 MG |
| Number | 3 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | LD84 |
| Extract | ISOFLAVONE FRACTION |
| Gender | FEMALE |