Experiment 68997
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | SUGIMOTO,KI: OHMORI,M: TSURUOKA,S: NISHIKI,K: KAWAGUCHI,A: HARADA,KI: ARAKAWA,M: SAKAMOTO,KI: MASADA,M: MIYAMORI,I: FUJIMURA,A:. (2001). DIFFERENT EFFECTS OF ST JOHN'S WORT ON THE PHARMACOKINETICS OF SIMVASTATIN AND PRAVASTATIN.. 70(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFECTS OF ST JOHN'S WORT ON THE PHARMACOKINETICS OF THE 3-HYDROXY-3-METHYLGLUTARYL COA REDUCTASE INHIBITORS SIMVASTATIN AND PRAVASTATIN WERE DETD. HEALTHY MALE SUBJECTS TOOK A ST JOHN'S WORT CAPLET (300MG) OR MATCHING PLACEBO THREE TIMES A DAY FOR 14 DAYS IN A DOUBLE-BLIND, CROSSOVER STUDY. ON DAY 14, A SINGLE ORAL DOSE OF 10 MG SIMVASTATIN OR 20 MG PRAVASTATIN WAS GIVEN. REPEATED ST JOHN'S WORT-TREATMENT TENDED TO LOWER PLASMA SIMVASTATIN CONCN. AND SIGNIFICANTLY LOWERED CONCENS. OF SIMVASTATIN HYDROXY ACID TENDED,ITS ACTIVE METABOLITE. THE PEAK CONCN. IN PLASMA OF SIMVASTATIN HYDROXY ACID TENDED TO BE DECREASED AND ITS AREA UNDER THE PLASMA CONCN.-TIME CURVE BETWEEN TIME ZERO AND 24 H AFTER ADMINISTRATION WAS SIGNIFICANTLY DECREASED BY ST JOHN'S WORT. ON THE OTHER HAND, ST HOHN'S WORT DID NOT INFLUENCE PLASMA PRAVASTATIN CONCN. ST JOHN'S WORT CAUSED NO SIGNIFICANT DIFFERENCES IN THE ELIMINATION HALF-LIFE OF SIMVASTATIN OR PRAVASTATIN. THUS, SR JOHN'S WORT DECREASES PLASMA CONCNS. OF SIMVASTATIN BUT NOT OF PRAVASTATIN. BECAUSE SIMVASTATIN IS EXTENSIVELY METABOLIZED BY CYTOCHROME P 4503A4 IN THE INTESTINAL WALL AND LIVER, WHICH IS INDUCED BY ST JOHN'S WORT, IT IS LIKELY THAT THIS INTERACTION IS PARTLY CAUSED BY THE ENHANCEMENT OF THE CYTOCHROME P 4503A4-MEDIATED 1ST-PASS METAB. OF SIMVASTATIN THE SMALL INTESTINE AND LIVER. |
| Dose amount | 900.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | MALE |