Experiment 69070

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismVaccinium macrocarpon (ERICACEAE)
CitationHOWELL,AB:. (2002). CRANBERRY JUICE AND ADHESION OF ANTIBIOTIC-RESISTANT UROPATHOGENS.. 287(23)
Amount utilized
Compound isolated
DiseaseTHIRTY-NINE UROPATHOGENIC P-FIMBRIATED E COLI ISOLATES WERE OBTAINED FROM WOMEN AGED 18 TO 39 YEAR WITH CLINICALLY DIAGNOSED, CULTURE-CONFIRMED OVER A 12-HOUR PERIOD FROM HEALTHY WOMEN BEFORE AND AFTER CONSUMPTION OF 240 ML OF COMMERCIAL CRANBERRY JUICE COCKTAIL, AND IN CRANBERRY PROANTHOCYANIDIN EXTRACT (PH6.5) (2-FOLD DILUTION SERIES). ISOLATES TESTED WERE A SUBSET OF THOSE PREVIOUSLY SCREENED FOR RESISTANCE; 24(62%) OF THOSE SELECTED WERE RESISTANT TO TRIMETHOPRIM SULFAMETHOXAZOLE. THESE BACTERIA WERE THEN HARVESTED AND SCREENED FOR ABILITY TO ADHERE TO ISOLATED UROEPITHELIAL CELLS, AGGLUTINATE HUMAN RED BLOOD CELLS (A1 RH+), AND RESIN BEADS COATED WITH ISOLATED P-RECEPTOR OLIGOSACCHARIDES. URINE AFTE CRANBERRY JUICE COCKTAIL CONSUMPTION (AVERAGE PH6.2) PREVENTED ADHESION OF 31(80%) OF BACTERICAL ISOLATES.
Dose amount240.0 ML
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitDAY
Dose expressionDOSE
ExtractJUICE
GenderFEMALE