Experiment 69089
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | DEMARLES,D: GILLOTIN,C: BONAVENTURE PACI,S: VINCENT,I: FOSSE,S: TABURET,AM:. (2002). SINGLE-DOSE PHARMACOKINETICS OF AMPRENAVIR COADMINISTERED WITH GRAPEFRUIT JUICE.. 46(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN CROSSOVER STUDY IN 12 HEALTHY VOLUNTEERS, COADMINISTRATION OF AMPRENAVIR (1200MG: SINGLE DOSE) WITH GRAPEFRUIT JICE SLIGHTLY REDUCED THE MAXIMUM CONCETRATION OF DRUG IN SERUM (C-MAX) COMPARED TO ADMINISTRATION WITH WATER (7.11 VERSUS 9.10 MCG/ML), SLIGHTLY INCREASED THE TIME TO C-MAX (1.13 VERSUS 0.75H), AND DID ONT AFFECT THE AREA UNDER THE CONCETRATION-TIME CURVE FROM 1 TO 12H (AUC-0-12), THE AUC(0-INFINITY), OR THE CONCENTRATION AT 12H. THEREFORE, GRAPEFRUIT JUICE DOES NOT CLINICALLY SIGNIFICANTLY AFFECT AMPRENAVIR PHARMACOKINETICS. |
| Dose amount | 200.0 ML |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | GIVEN TO BOTH SEXES |