Experiment 69161
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Crataegus oxyacantha (ROSACEAE) |
| Citation | BELZ,GG: BUTZER,R: GAUS,W: LOEW,D:. (2002). CAMPHOR-CRATAEGUS BERRY EXTRACT COMBINATION DOSE-DEPENDENTLY REDUCES TILT-INDUCED FALL IN BLOOD PRESSURE IN ORTHOSTATIC HYPOTENSION.. 9(7) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN ORDER TO TEST THE EFFICACY OF A COMBINATION OF NATURAL D-CAMPHOR AND AN EXTRACT OF FRESH CRATAEGUS BERRIES (KORODIN HERZ-DRISLAUF-TROPFEN) ON ORTHOSTATIC HYPOTENSION, TWO SIMILAR, CONTROLLED, RANDOMIZED STUDIES WERE CARRIED OUT IN A BALANCED CROSSOVER DESIGN IN 24 PATIENTS EACH WITH ORTHOSTATIC DYSREGULATION. THE CAMPHOR-CRATEGUS BERRY COMBINATION (CCC) WAS ORALLY ADMINISTERED AS A SINGLE REGIMEN IN 3 DIFFERENT DOSAGE OF 5 DROPS, 20 DROPS AND 80 DROPS; A PLACEBO WITH 20 DROPS OF A 60% ALCOHOLIC SOLUTION SERVED AS CONTROL. ORTHOSTATIC HYPOTENSION WAS ASSESSED WITH THE TILT TABLE TEST BEFORE AND AFTER MEDICATION. SOURCE DATA OF BOTH STUDIES WERE POOLED AND META-ANALYTICALLY EVALUATED FOR ALL 48 PATIENTS. CCC DROP DECREASED THE ORTHOSTATIC FALL IN BLOOD PRESSURE VERSUS PLACEBO, AS ALMOST UNIFORMLY ESTABLISHED AT ALL TIMES BY MEAN ARTERIAL PRESSURE AND DIASTOLIC BLOOD PRESSURE. MEAN ARTERIAL PRESSURE DEMONSTRATED THE VERY FAST ONSET OF ACTION BY A CLEARLY DOSE- DEPENDENT STATISTICALLY SIGNIFICANT EFFECT EVEN AFTER 1-MINUTE ORTHOSTASIS. INCREASE OF MEAN ARTERIAL PRESSURE AS COMPARED TO THE ORTHOSTASIS TEST BEFORE MEDICATION WAS ON AVERAGE 4.5 MM HG. CCC AFFECTED DIASTOLIC BLOOD PRESSURE AFTER 1 MINUTE OF ORTHOSTASIS IN ALL DOSAGES AS COMPARED TO PLACEBO. A STATISTICALLY SIGNIFICANT EFFECT OF THE HIGHEST DOSE OF 80 DROPS OF DIASTOLIC BLOOD PRESSURE COULD BE DEMONSTRATED AFTER 1, 3, AND 5 MINUTES OF ORTHOSTASIS. THE HEMODYNAMIC FINDINGS OF A STABILIZING EFFECT ON ARTERIAL PRESSURE IN ORTHOSTASIS CORROBORATE THE LONG-TERM MEDICAL EXPERIENCE WITH CCC AND JUSTIFY THE INDICATION ORTHOSTATIC HYPOTENSION. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | ETOH(60%)EXT |
| Gender | GIVEN TO BOTH SEXES |