Experiment 69168
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | SCHEMPP,CM: WINGHOFER,B: MULLER,K: SCHULTE MONTING,J: MANNEL,M: SCHOPF,E: SIMON,JC:. (2003). EFFECT OF ORAL ADMINISTRATION OF HYPERICUM PERFORATUM EXTRACT (ST. JOHN'S WORT) ON SKIN ERYTHEMA AND PIGMENTATION INDUCED BY UVB, UVA, VISIBLE LIGHT AND SOLAR SIMULATED RADIATION.. 17(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | SEVENTY TWO VOLUNTEERS OF SKIN TYPES II AND III WERE INCLUDED AND WERE DIVIDED INTO SIX GROUPS, EACH CONSISTING OF 12 VOLUNTEERS. AFTER BOTH SINGLE-DOSE AND STEADY-STATE ADMINISTRATION, NO SIGNIFICANT INFLUENCE ON THE ERYTHEMA-INDEX OR MELANIN-INDEX COULD BE DETECTED, WITH THE EXCEPTION OF A MARGINAL INFLUENCE ON UVB INDUCED PIGMENTATION (P=0.0471) IN THE SINGLE-DOSE STUDY. THE RESULTS DO NOT PROVIDE EVIDENCE FOR A PHOTOTOXIC POTENTIAL OF THE HYPERICUM EXTRACT LI 160 IN HUMANS WHEN ADMINISTERED ORALLY IN TYPICAL CLINICAL DOSES UP TO 1800 MG DAILY. |
| Dose amount | 1.8 GM |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |