Experiment 69274
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Rhodiola rosea (CRASSULACEAE) |
| Citation | SHEVTSOV,VA: ZHOLUS,BI: SHERVARLY,VI: VOLSKIJ,VB: KOROVIN,YP: KHRISTICH,MP: ROSLYAKOVA,NA: WIKMAN,G:. (2003). A RANDOMIZED TRIAL OF TWO DIFFERENT DOSES OF A SHR-5 RHODIOLA ROSEA EXTRACT VERSUS PLACEBO AND CONTROL OF CAPACITY FOR MENTAL WORK.. 10(2/3) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE STUDY WAS CARRIED OUT ON A HIGHLY UNIFORM POPULATION COMPRISING 161 CADETS AGED FROM 19 TO 21 YEARS. ALL GROUPS WERE FOUND TO HAVE VERY SIMILAR INITIAL DATA, WITH NO SIGNIFICANT DIFFERENCE WITH REGARD TO ANY PARAMETER. THE STUDY SHOWED A PRONOUNCED ANTIFATIGUE EFFECT REFLECTED IN AN ANTIFATIGUE INDEX DEFINED AS A RATIO CALLED AFI. THE VERUM GROUPS HAD AFI MEAN VALUES OF 1.0385 AND 1.0195 AND 1.0195, 2 AND 3 CAPSULES RESPECTIVELY, WHILST THE FIGURE FOR THE PLACEBO GROUP WAS 0.9046. THIS WAS STATISTICALLY HIGHLY SIGNIFICANT (P<0.001) FOR BOTH DOSES (VERUM GROUPS), WHILST NO SIGNIFICANT DIFFERENCE BETWEEN THE TWO DOSAGE GROUPS WAS OBSERVED. THERE WAS A POSSIBLE TREND IN FAVOUR OF THE LOWER DOSE IN THE PSYCHOMETRIC TESTS. NO SUCH TREND WAS FOUND IN THE PHYSIOLOGICAL TESTS. |
| Dose amount | 370.0 MG |
| Number | 2 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |
| Gender | GIVEN TO BOTH SEXES |