| Disease | PGI2 PRODUCTION BY THE ENDOTHELIAL CELLS AND PERHAPS PLATELET-ENRICHED LEVELS OF ARACHIDONIC ACID OR COX-1 ACTIVITY, OR BOTH, T2DM SUBJECTS.
URINARY PROSTANOID EXCRETION. G BILOBA-INDUCED REDUCTION OF BOTH CLASSES OF PROSTANOID METABOLITES IN HEALTHY VOLUNTEERS, BUT NOT IN T2DM SUBJECTS, MAY SUGGEST A NONSELECTIVE INHIBITION OF COX-1-MEDIATED TXA2 IN PLATELETS AND COX-2-MEDIATED
INGESTION DID NOT AFFECT PANCREATIC BETA-CELL FUNCTION BUT SIGNIFICANTLY REDUCED PLATELET AGGREGATION, CONVERTING 16 OF 19[COL+/EPI+] PLATELETS TO THE [COL-/EPI+]PHENOTYPE. UNLIKE THE HEALTHY VOLUNTEERS, THIS WAS NOT ACCOMPANIED BY A REDUCED
12.4(DL)-6.1 TO 10.3(DL)-6.1 NG/MG CR (P<0.04) AND PGI2 METABOLITES (2,3-DINOR-6-PGF1ALPHA AND 6-KETO-PGF1ALPHA) FROM 2.2(DL)-0.8 TO 1.8(DL)-0.8NG/MG CR(P<0.05). IN THE T2DM SUBJECTS (AGE, 54(DL)-8; BMI, 36.6(DL)-7.9KG/M2; N=19), G. BILOBA
RESPECTIVELY) AND SIGNIFICANTLY REDUCED COLLAGEN BUT NOT PAF-MEDIATED PLATELET AGGREGATION, CONVERTING 21 OF 28 SUBJECTS WITH [COL+/EPI+] PLATELETS TO THE [COL-/EPI+] PHENOTYPE. THIS WAS ACCOMPANIED BY A REDUCTION OF 11-DEHYDRO-TXB2 FROM
HEALTHY VOLUNTERRS (AGE, 42(DL)-11 YEARS; BMI, 28.4(DL)-4.8KG/M2; N=28),THE INGESTION OF G. BILOBA EXTRACT SIGNIFICANTLY INCREASED FASTING INSULIN AND C-PEPTIDE (10(DL)-4VS. 12(DL)-MUU/ML, P<0.007 AND 1.3(DL)-0.8VS.2.1(DL)-1.1 NG/ML, P<0.001, |