Experiment 69374
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | TASSANEEYAKUL,W: TASSANCEYAKUL,W: VANNAPRASAHT,S: YAMAZOE,Y:. (2001). FORMATION OF OMEPRAZOLE SULPHONE BUT NOT 5-HYDROXYOMEPRAZOLE IS INHIBITED BY GRAPEFRUIT JUICE.. 16() |
| Amount utilized | |
| Compound isolated | |
| Disease | SIMULTANEOUS ADMINISTRATION OF GRAPEFRUIT JUICE. LIQUID CHROMATOGRAPHY (H.P.L.C.). ADMINISTRATION OF GRAPEFRUIT JUICE DECREASED THE FORMATION OF OMEPRAZOLE SULPHONE BUT ONT 5-HYDROXYOMEPRAZOLE. THESE RESULTS INDICATE THAT ACTIVITIES OF CYP2A4, BUT NOT OF CYP2C19, ARE INHIBITED BY THE AND STANDARDIZED MEALS WERE SERVED 3 AND 10 HRS AFTER THE ADMINISTRATION OF OMEPRAZOLE. PLASMA CONCENTRATIONS OF OMEPRAZOLE AND ITS MAJOR METABOLITES, 5-HYDROXYOMEPRAZOLE AND OMEPRAZOLE SULPHONE, WERE DETERMINED BY HIGH PEROFRMANCE THIS WAS A RANDOMIZED CROSSOVER STUDY WITH 2 WEEKS WASH OUT PEROID. OMEPRAZOLE (20MG) WAS TAKEN ORALLY BY 13 HEALTHY VOLUNTEERS AFTER AN OVERNIGHT FAST WITH EITHER GRAPEFRUIT JUICE OR WATER. SERIAL BLOOD SAMPLES WERE OBTAINED OVER 12 HRS AND |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | GIVEN TO BOTH SEXES |