Experiment 69385
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Glycyrrhiza glabra (FABACEAE) |
| Citation | FUHRMAN,B: VOLKOVA,N: KAPLAN,M: PRESER,D: ATTIAS,J: HAYEK,T: AVIRAM,M:. (2002). ANTIATHEROSCLEROTIC EFFECTS OF LICORICE EXTRACT SUPPLEMENTATION ON HYPERCHOLESTEROLEMIC PATIENTS: INCREASED RESISTANCE OF LDL TO ATHEROGENIC MODIFICATIONS, REDUCED PLASMA LIPID LEVELS, AND DECREASED SYSTOLIC BLOOD PRESSURE.. 18() |
| Amount utilized | |
| Compound isolated | |
| Disease | EXTRACT BY HYPERCHOLESTEROLEMIC PATIENTS MAY ACT AS A MODERATE HYPOCHOLESTEROLEMIC NUTRIENT AND A POTENT ANTIOXIDANT AGENT AND, HENCE AGAINST CARDIOVASCULAR DISEASE. 1 MO OF PLACEBO CONSUMPTION, THESE PARAMETERS REVERSED TOWARD BASELINE LEVELS. LICORICE EXTRACT SUPPLEMENTATION ALSO REDUCED SYSTOLIC BLOOD PRESSURE BY 10%, WHICH WAS SUSTAINED DURING THE PLACEBO CONSUMPTION. DIETARY CONSUMPTION OF LICORICE-ROOT RETENTION, ESTIMATED AS CHONDROITIN SULFATE BINDING ABILITY (BY 25%); 3) REDUCED PLASMA CHOLESTEROL LEVELS (BY 5%), WHICH WAS DUE TO A 9% REDUCTION IN PLASMA LDD CHOLESTEROL LEVELS; AND 4) REDUCED (BY 14%) PLASMA TRIACYGLYCEROL LEVELS. AFTER THE PLACEBO CONSUMPTION. LICORICE CONSUMPTION 1) REDUCED PATIENT'S PLASMA SUSCEPTIBILITY TO OXIDATION (BY 19%); 2) INCREASED RESISTANCE OF PLASMA LDL AGAINST THREE MAJOR ATHEROGENIC MODIFICATIONS: OXIDATION (BY 55%) AGGREGATION (BY 28%), AND A STUDY-TO ANALYZE THE ANTIATHEROGENIC EFFECTS OF LICORICE-ROOT EXTRACT CONSUMPTION IN MODERATELY HYPERCHOLESTEROLEMIC PATIENTS. SUPPLEMENTATION OF LICORICE ROOT EXTRACT (0.1 G/D) TO PATIENTS FOR 1 MO WAS FOLLOWED BY AN ADDITIONAL 1 MO OF |
| Dose amount | 100.0 MG |
| Number | 3 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ETOH(95%)EXT |
| Gender | GIVEN TO BOTH SEXES |