Experiment 69394
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Eleutherococcus senticosus (ARALIACEAE) |
| Citation | MARKOWITZ,JS:. (2003). SIBERIAN GINSENG (ELEUTHEROCCUS SENTIOCOSUS) EFFECTS OF CYP2D6 AND CYP3A4 ACTIVITY IN NORMAL VOLUNTEERS.. 31(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | FOR ELIMINATION. (P>0.05). THE RESULTS INDICATE THE STANDARDIZED EXTRACTS OF SG AT GENERALLY RECOMMENDED DOSES FOR OVER-THE COUNTER USE ARE UNLIKELY TO ALTER THE DISPOSITION OF COADMINISTERED MEDICATIONS PRIMARILY DEPENDENT ON THE CYP2D6 OR CYP3A4 PATHWAYS WERE NO SIGNIFICANT DIFFERENCES IN THE PHARMACOKINETIC PARAMETERS DETERMINED BY NONCOMPARTMENTAL MODELING (C(MAX), T(MAX), AREA UNDER THE CURVE, HALF-LIFE OF ELIMINATION) INDICATING THAT SG DOES NOT SIGNIFICANTLY INDUCE OR INHIBIT CYP3A4 CHROMATOGRAPHY METHODS WERE USED TO QUANTIFY ALL COMPOUNDS AND RELEVENT METABOLITES. THERE WERE NO STATISTICALLY SIGNIFICANT DIFFERENCES BETWEEN PRE- AND POST-SG TREATMENT DMRS INDICATING A LACK OF EFFECT ON CYP2D6 (P>0.05). FOR ALPRAZOLAM THERE DETERMINED AT BASELINE AND AFTER SG TREATMENT. LIKEWISE, PLASMA SAMPLES WERE COLLECTED (0-60 H) FOR ALPRAZOLAM PHARMACOKINETICS AT BASELINE AND AFTER SG TRETMENT TO ASSESS EFFECTS ON CYP3A4 ACTIVITY. VALIDATED HIGH PERFORMANCE LIQUID ADMINISTERED ORALLY AT BASELINE AND AGAINST FOLLOWING TREATMENT WITH SG (1 X 485 MG TWICE DAILY) FOR 14 DAYS. URINARY CONCENTRATIONS OF DEXTROMETHORPHAN AND DEXTORPHAN WERE QUANTIFIED, AND DEXTROMETHORPAN METABOLIC RATIOS (DMRS) WERE A STUDY WAS TO ASSESS IN NORMAL VOLUNTEERS (N=12) THE INFLUENCE OF A STANDARDIZED SG EXTRACT ON THE ACTIVITY OF CYTOCHROME P450 CYP2D6 AND 3A4. PROBE SUBSTRATES DEXTROMETHORPHAN (CYP2D6 ACTIVITY) AND ALPRAZOLAM (CYP3A4 ACTIVITY) WERE |
| Dose amount | 970.0 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |