Experiment 69397
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | HALLER,CA: JACOB III,P: BENOWITZ,NL:. (2002). PHARMACOLOGY OF EPHEDRA ALKALOIDS AND CAFFEINE AFTER SINGLE-DOSE DIETARY SUPPLEMENT USE.. 71() |
| Amount utilized | |
| Compound isolated | |
| Disease | SUBJECTS WHO WERE NOT TAKING ORAL CONTRACEPTIVES. WERE INSIGNIFICANT. TWO SUBJECTS WHO WERE TAKING ORAL CONTRACEPTIVES HAD LONGER CAFFEINE HALF-LIVES (15.5 + 0.3 HOURS VERSUS 5.6 + 1.7 HOURS) AND LOWER VALUES FOR ORAL CLEARANCE (0.34 + 0.01 ML/MIN.KG VERSUS 0.99 + 0.41 ML/MIN.KG) THAN 14 MM HG ABOVE BASELINE AT 90 MINUTES AFTER INGESTION (P<.001). THERE WAS A LAG IN THE MEAN HEART RATE RESPONSE THAT REACHED A MAXIMUM CHANGE OF 15 BEATS/MIN ABOVE BASELINE AT 6 HOURS AFTER INGESTION (P<.001). DIASTOLIC BLOOD PRESSURE CHANGES WERE COMPARABLE TO PUBLISHED VALUES REPORTED FOR DRUG FORMULATIONS. A PROLONGED HALF-LIFE OF EPHEDRINE AND PSEUDOEPHEDRINE WAS OBSERVED IN 1 SUBJECT WITH HIGHEST URINE PH. MEAN SYSTOLIC BLOOD PRESSURE INCREASED SIGNIFICANTLY TO A MAXIMUM OF CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY FOR EPHEDRINE ALKALOID AND CAFFEINE CONCENTRATIONS, AND HEART RATE AND BLOOD PRESSURE WERE MONITORED FOR 14 HOURS. PLASMA CLEARANCE AND ELIMINATION HALF-LIVES FOR EPHEDRINE, PSEUDOEPHEDRINE, AND CAFFEINE EIGHT HEALTHY ADULTS RECEIVED A SINGLE ORAL DOSE OF A THERMOGENIC DIETARY SUPPLEMENT LABELED TO CONTAIN 20 MG EPHEDRINE ALKALOIDS AND 200 MG CAFFEINE AFTER AN OVERNIGHT FAST. SERIAL PLASMA AND URINE SAMPLES WERE ANALYZED BY USE OF LIQUID |
| Dose amount | 200.0 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |