Experiment 69400
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Ephedra sinica (EPHEDRACEAE) |
| Citation | SAMENUK,D: LINKS,MS: HOMOUD,MK: CONTRERAS,RBS: THEROHARDES,TC: WANG,PJ: ESTES III,NAM:. (2002). ADVERSE CARDIOVASCULAR EVENTS TEMPORALLY ASSOCIATED WITH MA HUANG, AN HERBAL SOURCE OF EPHEDRINE.. 77(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | HUANG REMAINS INCOMPLETELY DEFINED, AVAILABEL OBSERVATIONAL AND CIRCUMSTANTIAL EVIDENCE INDICATES THAT USE OF THE SUBSTANCE MAY BE ASSOCATED WITH SERIOUS MEDICAL COMPLICATIONS. VASCULAR DISESE IS NOT PREREQUISITE FOR AMA HUANG-RELATED ADVERSE EVENTS; AND (3) THE CARDIOVSACULAR TOXIC EFFECTS ASSOCIATED WITH MA HUANG WERE NOT LIMITED TO MASSIVE DOSES. ALTHOUGH THE PATHOGENESIS OF THE CARDIAC TOXIC EFFECTS OF MA HUANG WAS REPORTED TO BE WITHIN THE MANUFACTURERS' DOSING GUIDELINE. ANALYSIS OF THE 37 PATIENTS INDICATES THE FOLLOWING FINDINGS: (1) MA HUANG USE IS TEMPORALLY RELATED TO STOKE, MYOCARDIAL INFARCTION, AND SUDDEN DEATH; (2) UNDERLYING HEART OR INFARCTION (IN 10), OR SUDDEN DEATH (IN 11). AUTOPSIES PERFORMED IN 7 OF THE 11 PATIETNS WHO EXPERIENCED SUDDEN DEATH SHOWED A NORMAL HEART IN 1, CORONARY ATHEROSCLEROSIS IN 3, AND CARDIOMYOPATHIES IN 3. IN 36 OF THE 37 PATIENTS, USE OF MA 926 CAUSES OF POSSIBLE MA HUANG TOXICITY WERE REPORTED TO THE FOOD AND DRUG ADMINISTRATION. IN 37 PATIENTS (23 WOMEN AND 14 MEN WITH A MEAN +/-SD AGE OF 43 +/-13 YEARS), USE OF MA HUANG WAS TEMPORALLY RELATED TO STROKE (IN 16), MYOCARDIAL |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |
| Gender | GIVEN TO BOTH SEXES |