Experiment 69407
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Boswellia serrata (BURSERACEAE) |
| Citation | KIMMATKAR,N: THAWANI,V: HINGORANI,L: KHIYANI,R:. (2003). EFFICACY AND TOLERABILITY OF BOSWELLIA SERRATA EXTRACT IN TREATMENT OF OSTEOARTHRITIS OF KNEE. A RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED TRIAL.. 10() |
| Amount utilized | |
| Compound isolated | |
| Disease | PATEINTS OF OSTEOARTHRITIS OF THE KNEE WITH POSSIBLE THEAPEUTIC USE IN OTHER ARTHRITIS. THERE WAS NO CHANGE. THE OBSERVED DIFFERENCES BETWEEN DRUG TREATED AND PLACEBO BEING STATISTICALLY SIGNIFICANT, ARE CLINICALLY RELEVANT. BSE WAS WELL TOLERATED BY SUBJECTS EXCEPT FOR MINOR GASTROINTESTINAL ADRS. BSE IS RECOMMENDED IN THE THE OPPOSITE INTERVENTION FOR EIGHT WEEKS. ALL PATIENTS RECEIVING DRUG TREATMENT REPORTED DECREASE IN KNEE PAIN, INCREASED KNEE FLEXION AND INCREASED WALKING DISTANCE. THE FREQUENCY OF SWELLING IN THE KNEE JOINT WAS DECREASED. RADIOLOGICALLY TOLERABILITY OF BOSWELLIA SERRATA EXTRACT (BSE) IN 30 PATIENTS OF OSTEOARTHRITIS OF KNEE, 15 EACH RECEIVIENG ACTIVE DRUG OR PLACEBO FOR EIGHT WEEKS. AFTER THE FIRST INVERVENTION, WASHOUT WAS GIVEN AND THEN THE GROUPS WERE CROSSED OVER TO RECEIVE THE THERAPEUTIC VALUE OF ITS GUM (GUGGULU) HAS BEEN KNOWN. IT POSSES GOOD ANTI-INFLAMMATORY, ANTI-ARTHRITIC AND ANALGESIC ACTIVITY. A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED CROSSOVER STUDY WAS CONDUCTED TO ASSESS THE EFFICACY, SAFETY AND |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | DICHLOROMETHANE EXT |
| Gender | GIVEN TO BOTH SEXES |