Experiment 69416
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | WALKER,AF: BUNDY,R: HICKS,SM: MIDDLETON,RW:. (2002). BROMELAIN REDUCES MILD ACUTE KNEE PAIN AND IMPROVES WELL-BEING IN A DOSE-DEPENDENT FASHION IN AN OPEN STUDY OF OTHERWISE HEALTHY ADULTS.. 9(8) |
| Amount utilized | |
| Compound isolated | |
| Disease | DEPENDANT MANNER. AGAIN, A SIGNIFICANTLY DOSE-RESPONSE RELATIONSHIP WAS OBSERVED. WE CONCLUDE THAT BROMELAIN MAY BE EFFECTIVE IN AMELIORATING PHYSICAL SYMPTOMS AND IMPROVING GENERAL WELL-BEING IN OTHERWISE HEALTHY ADULTS SUFFERING FROM MILD KNEE PAIN IN A DOSE- DOSE (400 MG PER DAY) COMPARED WITH THE LOW-DOSE GROUP. COMPARED TO BASELINE, OVERALL PSYCHOLOGICAL WELL-BEING WAS SIGNIFICANTLY IMPROVED IN BOTH GROUPS AFTER TREATMENT (P=0.015 AND P-0.0003 IN THE LOW AND HIGH DOSE GROUPS RESPECTIVELY), AND 59% (P-0.0001 AND <0.0001) IN THE LOW AND HIGH DOSE GROUPS RESPECTIVELY. IN ADDITION, IMPROVEMENTS IN TOTAL SYMPTOMS SCORE (P=0.036) AND THE STIFFNESS (P=0.026) AND PHYSICAL FUNCTION (P=0.021) DIMENSIONS WERE SIGNIFICANTLY GREATER IN THE HIGH- 400 MG PER DAY. SEVENTY SEVEN SUBJECTS COMPLETED THE STUDY. IN BOTH TREATMENT GROUPS, ALL WOMAC SYMPTOM DIMENSION SCORES WERE SIGNIFICANTLY REDUCED COMPARED WITH BASELINE, WITH REDUCTIONS IN THE FINAL BATTERY (TOTAL SYMPTOM SCORE) OF 41 AND AND MAGAZINE ARTICLES. TWO VALIDATED QUESTIONNAIRES (WOMAC KNEE HEALTH INDEX AND PSYCHOLOGICAL WELL-BEING INDEX) WERE COMPLETED AT BASELINE AND AFTER ONE MONTH'S INTERVENTION WITH BROMELAIN, RANDOMLY ALLOCATED TO VOLUNTEERS AS EITHER 200 MG OR THE CURRENT STUDY INVESTIGATED THE EFFECTS OF BROMELAIN ON MILD ACUTE KNEE PAIN OF LESS THAN 3 MONTHS DURATION IN OTHERWISE HEALTHY ADULTS. THE STUDY WAS AN OPEN, DOSE-RANGING POSTAL STUDY IN VOLUNTEERS WHO HAD BEEN RECRUITED THROUGH NEWSPAPER |
| Dose amount | 400.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |