Experiment 69417
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | KOHLERT,C: SCHINDLER,G: MARZ,RW: ABEL,G: BRINKHAUS,B: DERENDORF,H: GRAFE,EU: VEIT,M:. (2002). SYSTEMIC AVAILABILITY AND PHARMACOKINETICS OF THYMOL IN HUMANS.. 42(7) |
| Amount utilized | |
| Compound isolated | |
| Disease | BOTH THYMOL SULFATE AND GLUCURONIDE EXCRETED IN 24-HOUR URINE WAS 16.2% + 4.5% OF THE DOSE. 24.5 NG ML-1 AND WERE REACHED AFTER 2.0 + 0.8 HOURS. THE MEAN TERMINAL ELIMINATION HALF-LIFE WAS 10.2 HOURS. THYMOL SULFATE WAS DETECTABLE UP TO 41 HOURS AFTER ADMINISTRATION. URINARY EXCRETION COULD BE FOLLOWED OVER 24 HOURS. THE AMOUNT OF ENZYMATIC HYDROLYSIS OF THE METABOLITIES BY HEADSPACE SOLID-PHASE MICROEXTRACTION PRIOR TO GC ANALYSIS AND FLAME IONIZATION DETECTION. THYMOL SULFATE, BUT NOT THYMOL GLUCURONOIDE, WAS DETECTABLE IN PLASMA. PEAK PLASMA CONCENTRATIONS WERE 93.1 + EQUIVALENT TO 1.08 MG THYMOL. NO THYMOL COULD BE DETECTED TO PLASMA OR URINE. HOWEVER, THE METABOLIETES THYMOL SULFATE AND THYMOL GLUCURONIDE WERE FOUND IN URINE AND IDENTIFIED BY LC-MS/MS. PLASMA AND URINE SAMPLES WERE ANALYZED AFTER TO DETERMINE THE SYSTEMIC AVAILABILITY AND THE PHARMACOKINETICS OF THYMOL AFTER ORAL APPLICATION TO HUMANS, A CLINICAL TRAIL WAS CARRIED OUT IN 12 HEALTHY VOLUNTEERS. EACH SUBJECT RECEIVED A SINGLE DOSE OF A BRONCHIPRET TP TABLET, WHICH IS |
| Dose amount | 1.08 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |