Experiment 69418
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Cynara scolymus (ASTERACEAE) |
| Citation | HOLTMANN,G: ADAM,B: HAAG,S: COLLET,W: GRUNEWALD,E: WINDECK,T:. (2003). EFFICACY OF ARTICHOKE LEAF EXTRACT IN THE TREATMENT OF PATIENTS WITH FUNCTIONAL DYSPEPSIA: A SIX-WEEK PLACEBO-CONTROLLED, DOUBLE-BLIND, MUTICENTRE TRIAL.. 18() |
| Amount utilized | |
| Compound isolated | |
| Disease | SIGNIFICANTLY BETER THAN THE PLACEBO IN ALLEVIATING SYMPTOMS AND IMPROVING THE DISEASE-SPECIFIC QUALITY OF LIFE IN PATIENT WITH FUNCTIONAL DYSPEPSIA. SIMILARLY, PATIENTS TREATED WITH ALE SHOWED SIGNIFICANTLY GREATER IMPROVEMENT IN THE GLOBAL QUALITY-OF-LIFE SCORES (NDI) COMPARED WITH THE PLACEBO-TREATED PATIENTS (-41.1 +/-47.6 VS. -24.8 +/-35.6, PZ0.001). THE ALE PREPARATION TESTED WAS 115 PLACEBO) WERE SUITABEL FOR INCLUSION I THE STATISTICAL ANALYSIS (INTENTION-TO-TREAT). THE OVERALL SYMPTOM IMPROVEMENT OVE THE 6 WEEKS OF TREATMENT WAS SIGNIFICANTLY GREATER WITH ALE THAN WITH THE PLACEBO (8.3 +/4.6, VS 6.7 +/-4.8, P<0.01). SECONDARY VARIABLES WERE THE SCORES OF EACH DYSPEPTIC SYMPTOM AND THE QUALITY OF LIFE (QOL) AS ASSESSED BY THE NEPEAN DYSPEPSIA INDEX (NDI). TWO HUNDRED AND FORTY-SEVEN PATIENTS WERE ENROLLED, AND DATE FROM 244 PATIENTS (129 ACTIVE TREATMENT, TREATED WITH EITHER A COMMERICAL ALE PREPARATION (2X X 320 MG PLANT EXTRACT T.D.S.) OR A PLACEBO. THE PRIMARY EFFICACY VARIABLE WAS THE SUN SCORE OF THE PATIENT'S WEEKLY RATING OF THE OVERALL CHANGE IN DYSPEPTIC SYMPTOMS (FOUR-POINT SCALE). THIS STUDY AIMED TO ASSESS THE EFFICACY FO ARTICHOKE LEAF EXTRACT (ALE) IN THE TREATMENT OF PATIENTS WITH FUNCTIONAL DYSPEPSIA (FD). IN A DOUBLE-BLIND, RANDOMIZED CONTROLLED TRAIL (RCT). 247 PATIENTS WITH FUNCTIONAL DYSPEPSIA WERE RECRUITED AND |
| Dose amount | 640.0 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | H2O EXT |
| Gender | GIVEN TO BOTH SEXES |