Experiment 694297
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | PITOT,HC: MC ELROY JR,EA: REID,JM: WINDEBANK,AJ: SLOAN,JA: ERLICHMAN,C: BAGNIEWSKI,PG: WALKER,DL: RUBIN,J: GOLDBERG,RM: ADJEI,AA: AMES,MM:. (1999). PHASE I TRIAL OF DOLASTATIN-10 (NSC 376128) IN PATIENTS WITH ADVANCED SOLID TUMORS.. 5(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | PHARMACOKINETIC STUDIES DEMOONSTRATED A RAPID DRUG DISTRIBUTION WIH A PROLONGED PLASMA ELIMINATION PHASE (T1/2Z=320 MIN). THE AREA UNDER THE CONCENTRATION-TIME CURVE INCREASED INPROPORTION TO ADMINISTERED DOSE, WHEREAS THE CLEARNACE REMAINED CONSTANT OVER THE DOSES STUDIED. CORRELATION ANALYSIS DEMONSTRATED A STRONG RELATIONSHIP BETWEEN DOLA-10 UNDER THE CONCENTRATION-TIME CURVE VALUES AND DECREASE FROM BASELINE FOR LEUKOCYTE COUNTS. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |