Experiment 69446

Worktypes

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismTrifolium pratense (FABACEAE)
CitationBLAKESMITH,SJ: LYON-WALL,PM: GEORGE,C: JOANNOU,GE: PETOCZ,P: SAMMAN,S:. (2003). EFFECTS OF SUPPLEMENTATION WITH PURIFIED RED CLOVER (TRIFOLIUM PRATENSE) ISOFLAVONES ON PLASMA LIPIDS AND INSULIN RESISTANCE IN HEALTHY PREMENOPAUSAL WOMEN.. 89()
Amount utilized
Compound isolated
DiseaseRESISTANCE IN PREMENOPAUSAL WOMEN, A GROUP WHICH IS AT LOW RISK OF CHD. LDL-AND HDL-CHOLESTEROL, HDL SUBFRACTIONS, TRIACYLGLYCEROL, LIPOPROTEIN(A), GLUCOSE OR INSULIN CONCENTRATIONS. OUR PRESENT RESULTS INDICATE THAT PURIFIED ISOFLAVONES DERIVED FROM RED CLOVER HAVE NO EFFECT ON CHOLESTEROL HOMEOSTASIS OR INSULIN FOR FOUR MENSTRUAL CYCLES. BLOOD SAMPLES WERE COLLECTED WEEKLY DURING 1,3 AND 4. SUPPLEMENTATION WITH ISOFLAVONES RESULTED IN A 15-FOLD INCREASE IN URINARY ISOFLAVONE EXCRETION (P<0.0001). THERE WERE NO SIGNIFICANT EFFECTS ON TOTAL CHOLESTEROL, PARALLEL STUDY. THE TREATMENT GROUP (N 12) CONSUMED A PLACEBO FOR THE FIRST MENSTRUAL CYCLE AND AN ISOFLAVONE SUPPLEMENT (86 MG/D, DERIVED FROM RED CLOVER) FOR THREE CYCLES, WHILE THE PLACEBO GROUP (N 13) CONSUMED A PLACEBO SUPPLEMENT A PARALLEL STUDY DESIGNED TO RE-EXAMINE THE EFFECTS OF PURIFIED ISOFLAVONES ON PLASMA LIPOPROTEINS AND MARKERS OF INSULIN RESISTANCE IN PREMENOPAUSAL WOMAN. TWENTY-FIVE HEALTHY PREMENOPAUSAL WOMEN PARTICIPATED IN A DOUBLE-BLIND, RANDOMISED,
Dose amount86.0 MG
Number1
Qualitative resultINACTIVE
AnimalHUMAN ADULT
Per unitDAY
Dose expressionDOSE
ExtractISOFLAVONE FRACTION
GenderFEMALE