Experiment 694546
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Empty organism |
| Citation | AZUMA,K: IPPOUSHI,K: NAKAYAMA,M: ITO,H: HIGASHIO,H: TERAO,J:. (2000). ABSORPTION OF CHLOROGENIC ACID AND CAFFEIC ACDI IN RATS AFTER ORAL ADMINISTRATION.. 48(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | ABSORPTION OF ORALLY ADMINISTERED CHLOROGENIC ACID(5-CAFFEOYLQUINIC ACID) AND CAFFEIC ACID IN RATS WAS STUDIED TO OBTAIN PLASMA PHARMACOKINETIC PROFILES OF THEIR METABOLITES. RATS WERE ADMINISTERED 700 MICROMOL/KG BODY WEIGHT OF CHLOROGENIC OR CAFFIC ACID, AND BLOOD WAS COLLECTED FROM THE TAIL FOR 6 H AFTER ADMINISTRATION. INGESTED CAFFIC ACID WAS ABSORBED FROM THE ALIMENTARY TRACT AND WAS PRESENT IN THE RAT BLOOD CIRCULATION IN THE FORM OF VARIOUS METABOLITES. ON THE OTHER HAND, ONLY TRACES OF METABOLITES, SUPPOSEDLY CAFFEIC AND FERULIC ACIDS CONJUGATES, WERE DETECTED IN RAT PLASMA FOR 6 H AFTER CHLOROGENIC ACID ADMINISTRATION. CHLOROGENIC ACID AND SMALL AMOUNTS OF CAFFIC ACID WERE FOUND IN THE SMALL INTESTINE FOR 6 H AFTER CHLOROGENIC ACID ADMINISTRATION. THESE RESULTS SUGGEST THAT CHLOROGENIC ACID IS NOT WELL ABSORBED FROM THE DIGESTIVE TRACT, UNLIKE CAFFEIC ACID, AND SUBJECT TO ALMOST NO STRUCTURAL CHANGES TO THE EASILY ABSORBED FORMS. |
| Dose amount | 700.0 MICROMOLS |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |