Experiment 69467
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | TANAKA,T: KAWANO,K: OKUMURA,K: ORII,Y: TANIGAWA,T: TSUBOI,T: HASHIZUME,K: YUASA,H: KATO,M: WAKAYAMA,N: HASHIMOTO,K: SEKINO,H: MATSUOKA,O: KAMATA,S: NOMURA,M: TATEISHI,T:. (2001). EFFECT OF GRAPEFUIT JUICE ON THE PHARMACKONETICS OF ADALAT CR.. 32(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | AND CLEARNACE DECREASED SIGNIFICANTLY AFTER THE ADMINISTRATION OF ADALAT CR WITH GFJ, IT IS RECOMMENDED TO ADVISE PATIENTS TO AVOID INTAKE OF GFJ WHEN ADALAT CR IS ADMINISTERED. NISOLDIPINE OR FELODIPINE. THERE WAS AN INCREASE IN PLASMA DRUG CONCN. AFTER ADMINISTRATION OF ADALAT CR WITH GFJ, BUT THIS WAS WITHIN THE SAFE RANGE. NO MARKED INTERACTION ADALATA CR WITH GJF WAS FOUND. HOWEVER, SINCE THE CMAX AND AUC INCREASE PLASMA CONCNS. OF NIFEDIPINE AND ITS PLASMA AND URINARY METABOLITES WERE MEASURED. CHANGES IN THE PHARMACKOKINETICS OF NIFEDIPINE FROM ADALAT CR GIVEN WITH GFJ WERE LESS THAN THOSE OF OTHER DIHYDROPYRIDINES KNOWN TO INTERACT WITH GFJ, I.E., THE GASTROINTESTINAL TRACT. SINGLE DOSES AND 20 AND 40 MG ADALAT WERE ADMINSTERED WITH 250 ML OF GJF OR WATER TO HEALTHY YOUNG MALE JAPANESE VOLUNTEERS BY A 4-TREATMENT AND 4-PEROID CROSSOVER METHOD, WITH A 7-DAY WASHOUT BETWEEN TREATMENT. THIS WORK INVESTIGATED THE EFFECT OF GRAPEFRUIT JUCIE (GFJ) ON THE PHARMACOKINETICS OF THE NEW NIFEDIPINE FORMULATION ADALAT CR (CONTROLLED-RELEASE), A ONCE-DAILY SLOW-RELEASE (COAT-CORE) TABLET FORMULATED TO RELEASE NIFEDIPINE THROUGHTOUT |
| Dose amount | 250.0 ML |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | MALE |