Experiment 69473

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismCitrus paradisi (RUTACEAE)
CitationCASTRO,N: JUNG,H: MEDINEA,R: GONZALEZ-ESQUIVEL,D: LOPEZ,M: SOTELO,J:. (2002). INTERACTION BETWEEN GRAPEFRUIT JUICE AND PRAZIQUANTEL IN HUMANS.. 46(5)
Amount utilized
Compound isolated
Disease+128.5 NG/ML; AND CMAX FOR GRAPEFRUIT JUICE TREATMENT, 1,037.65+205.7 NG/ML, P<0.05). NO STATISTICALLY SIGNIFICANT DIFFERENCES WERE FOUND IN THE TIME TO MAXIMUM CONCENTRATION OF DRUG IN PLASMA OR ELIMINATION HALF-TIME. AFTER A SINGLE ORAL DOSE PF PRAZIQUANTEL WITH 250 ML OF GRAPEFRUIT JUICE, THE AREA UNDER THE CONCENTRATION-TIME CURVE AND THE MAXIMUM CONCENTRATION IN PLASMA OF PRAZIQUANTEL (CMAX) WERE SIGNIFICANTLY INCREASED (CMAX FOR WATER TREATMENT, 637.71
Dose amount250.0 ML
Number1
Qualitative resultINACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE
ExtractJUICE
GenderGIVEN TO BOTH SEXES