Experiment 69488
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Glycyrrhiza glabra (FABACEAE) |
| Citation | STRANDBERG,TE: JARVENPAA,AL: VANHANEN,H: MC KEIGUE,PM:. (2001). BIRTH OUTCOME IN RELATION TO LICORICE CONSUMPTION DURING PREGNANCY.. 153(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | PREGNANCY DID NOT SIGNIFICANTLY AFFECT BIRTH WEIGHT OR MATERNAL BLOOD PRESSURE; BUT IT WAS SIGNIFICANTLY ASSOCIATION WITH LOWER GESTATIONAL AGE. MEAN, THIS SHIFT TO THE LEFT OF THE DISTRIBUTION OF DURATION OF GESTATION WAS SUFFICIENT TO DOUBLE THE RISK OF BEING BORN BEFORE 38 WEEKS. THE ASSOCIATION REMAINED IN MULTIVARIATE ANALSYSES. IN CONCLUSION, HEAVY GLYCYRRHIZIN EXPOSURE DURING ODDS RATIO OR BEING BORN BEFORE 38 WEEKS GESTATION WAS 2.5 (95% CONFIDENCE INTERVAL: 1.1, 5.5; P=0.03). ALTHOUGH THE EFFECT OF HEAVY GLYCYRRHIZIN INTAKE ON MEAN DURATION OF GESTATION WAS SMALL (2.52 DAYS ) WHEN EXPRESSED AS AN EFFECT ON THE WEIGHT AND GESTATIONAL AGE (FROM ULTRASOUND MEASUREMENTS) WERE OBTAINED FROM HOSPITAL RECORDS. BABIES WITH HEAVY EXPOSURE TO GLYCYRRHIZIN WERE NOT SIGNIFICANTLY LIGTHER AT BIRHT, BUT THEY WERE SIGNIFICANTLY MORE LIKELY TO BE BORN EARLIER: THE GLYCYRRHIZIN INTAKE WAS CALCULATED FROM DETAILED QUESTIONNAIRES ON LICORICE CONSUMPTION. GLYCYRHIZIN EXPOSURE WAS GROUPED INTO THREE LEVELS: LOW (<250 MG/WEEK; N=751), MODERATE (250-499 MG/WEEK: N-145), AND HEAVY (2500 MG/WEEK; N=110). BIRTH A STUDY TO DETERMINE WHETHER MATERNAL CONSUMPTION OF GLYCYRRHIZIN ( AN INHIBITOR OF CORTISOL METABOLISM) IN LICORICE AFFECT BIRTH WEIGHT IN HUMANS. A SAMPLE OF 1,049 FINNISH WOMEN AND THEIR HEALTHYL SINGLETON INFANTS WAS STUDIED IN 1998. |
| Dose amount | 250.0 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |
| Gender | FEMALE |