Experiment 69489
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Allium sativum (LILIACEAE) |
| Citation | MC NULTY,CAM: WILSON,MP: HAVINGA,W: JOHNSTON,B: O'GARA,EA: MASLIN,DJ:. (2001). A PILOT STUDY TO DETERMINE THE EFFECTIVENESS OF GARLIC OIL CAPSULES IN THE TREATMENT OF DYSPEPTIC PATIENTS WITH HELICOBACTER PYLORI.. 6(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | INCREASING BACTERIAL DIVISION, MAY INCREASE THE IN VIVO ACTIVITY OF GARLIC OIL. THIS MAY BE WORTH PURSUING IN A FUTURE TRIAL. EFFECTIVE. ANTIBIOTICS ARE USUALLY COMBINED WITH A PROTON-PUMP INHIBITOR OR BISMUTH SALT, AS THE ONLY ANTIBIOTIC WITH ANY IN VIVO ACTIVITY AGAINST H.,PYLORI IN MONOTHERAPY IS CLARITHROMYCIN. A PROTON PUMP INHIBITOR RAISES GASTRIC PH AND, BY SUPPRESSION OF H. PYLOR OR SYMPTOM IMPROVEMENT WHILE TAKING GARLIC OIL.THESE NEG. RESULTS SHOW THAT , WITHING THE GASTRIC MUILIEU, GARLIC OIL AT THIS DOSE DOES NOT INHIBIT H.PYLOR. A HIGHER DOSE ADMINSITERED FOR A LONGER TIME-PERIOD MAY BE ERADICATON WAS DEFINED AS A NEG UBT AT BOTH FOLLOW-UP APPOINTMENTS. SUPPRESSION WAS DEFINED AS A 50% FALL IN 13C EXCE3SS BETWEEN BASELIND AND FOLLOW-UP 1. FIVE PATIENTS COMPLETED THE STUDY. THERE WAS NO EVIDENCE OF EITHER ERADICATION OR IN THIS PILOT STUDY DYSPEPTIC PATIENTS WITH POS. SEROL. FOR H. PYLORI CONFIRMED BY 13C UREA BREATH TEST (UBT), AT 0 AND 2 WK, WERE ENROLLED. TREATMENT CONSISTED OF ONE 4 MG GARLIC OIL CAPSULE WITH A MEAL FOUR TIMES PER DAY FOR 14 DAYS. H.PYLORI |
| Dose amount | 4.0 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ESSENTIAL OIL |
| Gender | GIVEN TO BOTH SEXES |