| Disease | THE ADSORPTION AND TURNOVER OF CAMPESTANOL BY THE PLASMA DUAL-ISOTOPE RATIO METHOD AND MATHEMATICAL ANALYSIS OF SPECIFIC ACTIVITY VERSUS TIME DECAY CURVES AFTER SIMULTANEOUS ORAL AND INTRAVENOUS PULSE-LABELING WITH CAMPESTANOL, RESPECTIVELY. IN
NEW ZEALAND WHITE (NZW) RABBITS: SIX FED CHOW AND SIX FED CHOW WITH 125 MG/D CAMPESTANOL AND 175 MG/DL WITH (24-ETHYL-5ALPHA-CHOLESTAN-3BETA-OL). PLASMA CONCENTRATIONS INCREASED INSIGNIFICANTLY FROM 0.08 (DL) 0.01 TO 0.09 (DL) 0.01 MG/DL WITH
DIETARY STANOLS. THE PERCENT CAMPESTANOL ABSORPTION MEASURED BY THE PLASMA DUAL-ISOTOPE RATIO METHODAFTER THE RABBITS WERE FASTED FOR 6 HOURS YIELDED THE PERCENT ABSORPTION IN THE ABSENCE OF COMPETING INSTESTINAL STEROIDS AND STANOLS AND
DECLINED INSIGNIFICANTLY FROM 11.6% (DL) 3.5% IN CONTROLS TO 8.1% (DL) 3.7% IN THE TREATED RABBIT GROUPS. IN CONTRAST, THE TURNOVER, WHICH MEASURED ACTUAL ABSORPTION AVERAGED OVER 24 HOURS, INCREASED FROM 0.12(DL) 0.05 TO 0.37(DL) 0.05 MG/D (P<.
.05) WITH CAMPESTANOL AND SITOSTANOL ADDED TO THE DIET. HOWEVER, THE ACTUAL PERCENT ABSORPTION DECLINED FROM 3% TO 0.3% OF DIETARY INTAKE WITH THE CAMPESTANOL AND SITOSTANOL-ENRICHED DIET. CAMPESTANOL POOL SIZES, ALTHOUGH REMAINING SMALL,
INCREASED SLIGHTLY FROM 1.1 (DL) 0.4 TO 2.5 (DL) 1.5 MG. THE RESULTS DEMONSTRATE SMALL CAMPESTANOL PLASMA CONCENTRATIONS AND BODY POOLS EVEN WHEN THE RABBITS CONSUMED SUBSTANTIAL AMOUNTS BECAUSE (1) INTESTINAL ABSORPTION WAS LIMITED AND (2) WAS
FURTHER REDUCED BY COMPETING DIETARY SITOSTANOL, AND (3) CAMPESTANOL WAS REMOVED RAPIDLY FROM THE BODY. THUS, CAMPESTANOL WHICH SHARES THE SAME BASIC STRUCTURE AND INTESTINAL ABSORPTION PATHWAY WITH CHOLESTEROL, DOES NOT ACCUMULATE WHEN FED, AND
MAY BE INCORPORATED INTO THE DIET TO BLOCK CHOLESTROL ABSORPTION. |