Experiment 69602
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Echinacea purpurea (ASTERACEAE) |
| Citation | MATTIAS,A: ADDISON,RS: PENMAN,KG: DICKINSON,RG: BONE,KM: LEHMANN,RP:. (2005). ECHINACEA ALKAMIDE DISPOSITION AND PHARMACOKINETICS IN HUMANS AFTER TABLET INGESTION.. 77() |
| Amount utilized | |
| Compound isolated | |
| Disease | DIFFERENCES WERE OBSERVED IN THE PHARMACOKINETICS OF INDIVIDUAL OR TOTAL ALKAMIDES IN 2 ADDITIONAL FASTED SUBJECTS WHO TOOK THE SAME DOSE OF THE ECHINACEA PREPARATION. THIS SINGLE DOSE STUDY PROVIDES EVIDENCE THAT ALKAMIDES ARE ORALLY AVAILABLE 12H. CONCENTRATION-TIME CURVES FOR 2,4-DIENE AND 2-ENE ALKAMIDES WERE DETERMINED. THE MAXIMAL CONCENTRATIONS FOR THE SUM OF ALKAMIDES IN HUMAN PLASMA WERE REACHED WITHIN 2.3 H. POST INGESTION AND AVERAGED 336+-131 NG EQ/ML PLASMA. NO OBVIOUS WERE OBTAINED. CAFFEIC ACID CONJUGATES COULD NOT BE IDENTIFIED IN ANY PLASMA SAMPLE AT ANY TIME AFTER TABLET INGESTION. ALKAMIDES WERE RAPIDLY ABSORBED AND WERE MEASURABLE IN PLASMA 20 MIN AFTER TABLET INGESTION AND REMAINED DETECTABLE FOR UP TO IN THIS INVESTIGATION, SERIAL PLASMA SAMPLES FROM 9 HEALTHY VOLUNTEERS WHO INGESTED ECHINACEA TABLETS MANUFACTURED FROM ETHANOLIC LIQUID EXTRACTS OF ECHINACEA ANGUSTIFOLIA AND ECHINACEA PURPUREA IMMEDIATELY AFTER A STANDARD HIGH FAT BREAKFAST AND THAT THEIR PHARMACOKINETICS ARE IN AGREEMENT WITH ONE DOSE THREE TIMES DAILY REGIMEN ALREADY RECOMMENDED FOR ECHINACEA. |
| Dose amount | 675.0 MG |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |