Experiment 69613
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | HENNESSAY,M: KELLEHER,D: SPIERS,JP: BARRY,M: KAVANAGH,P: BACK,D: MULCAHY,F: FEELY,J:. (2002). ST JOHN'S WORT INCREASES EXPRESSION OF P-GLYCOPROTEIN: IMPLICATIONS FOR DRUG INTERACTIONS.. 53(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | CTION OF THE MULTI DRUG TRANSPORTER P-GLYCOPROTEIN IN PBMCS OF HEALTHY VOLUNTEERS. EFFLUX IN BOTH GROUPS PRODUCING GREATER INTRACELLULAR ACCUMULATION OF RHODAMINE. HOWEVER, THIS EFFECT WAS ATTENUATED FOLLOWING TREATMENT WITH SJW (23.9+/- 15.3% VS 75.4 +/- 16.4% P >0.05. SJW INCREASED EXPRESSION AND ENHANCED THE DRUG EFFLUX FUN ARE EXPRESSED AS MEAN +/- S.D. AND WERE SUBJECTED TO NONPARAMETRIC ANALYSIS.P-GLYCOPROTEIN EXPRESSION INCREASED 4.2 FOLD FROM BASELINE IN SUBJECTS TREATED WITH SJW. THERE WAS NO EFFECT WITH RITONAVIR (5 MICROM) INHIBITED P-GLYCOPROTEIN MEDIATED OBTAINED. VIMENTIN AND IE WERE USED AS CONTROLS. THE PRESENCE OF THE MDR 1 GENE PRODUCT WAS CONFIRMED BY RT-PCR. P-GLYCOPROTEIN MEDIATED DRUG EFFLUX WAS DETERMINED AS A FUNCTION OF RHODAMINE EFFLUX IN THE ABSENCE AND PRESENCE OF RITONAVIR. DATA BLOOD LYMPHOCYTES (PBMCS) WERE ISOLATED BY FICOLL DENSITY GRADIENT CENTRIFUGATION, FIXED AND PERMEABLIZED. CELLS WERE STAINTED WITH A P-GLYCOPROTEIN SPECIFIC ANTIBODY, QUANTIFIED BY FLOW CYTOMETRY AND MEDIAN FLUORESCENCE INTENSITY (MFI) VALUES . HEALTHY VOLUNTEERS WERE RANDOMIZED TO EITHER SJW (0.15%) 600 MG THREE TIMES DAILY FOR 16 DAYS (N=15) OR PLACEBO (N=7). BLOOD SAMPLES WERE OBTAINED FOR P-GLYCOPROTEIN EXPRESSION AND FUNCTION AT BASELINE, 16 AND 32 DAYS POST TREATMENT. PERIPHERAL |
| Dose amount | 1.8 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |