Experiment 69646
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Petasites hybridus (ASTERACEAE) |
| Citation | POTHMANN,R: DANESCH,U:. (2005). MIGRAINE PREVENTION IN CHILDREN AND ADOLESCENTS; RESULTS OF AN OPEN STUDY WITH A SPECIAL BUTTERBUR ROOT EXTRACT.. 45(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | PROPHYLAXIS ALSO FOR CHILDREN AND TEENAGERS. PECTIVE MIGRAINE PREVENTION STUDY IN CHILDREN AND ADOLESCENTS ARE SIMILAR TO THE RESULTS OF TWO MULTICENTER PLACEBO-CONTROLLED BUTTERBUR STUDIES IN ADULTS. BUTTERBUR ROOT EXTRACT SHOWS A POTENTIAL AS AN EFFECTIVE AND WELL-TOLERATED MIGRAINE OR EVEN IMPROVED WELLBEING. UNDESIRED EFFECTS (7.4%) INCLUDED MOSTLY ERUCTATION. NO SERIOUS ADVERSE EVENTS OCCURED AND NO ADVERSE EVENT CAUSED A PREMATURE TERMINATION. CONCLUSIONS: THE RESULTS AND LOW RATE OF ADVERSE EVENTS IN THIS OPEN PROS- IN THE FREQUENCY OF MIGRAINE ATTACKS OF AT LEAST 50%. ATTACK FREQUENCY WAS REDUCED BY 63%, 91% OF PATIENTS FELT SUBSTANTIALLY OR AT LEAST SLIGHTLY IMPROVED AFTER 4 MONTHS OF TREATMENT. ABOUT 90% OF EACH, DOCTORS AND PATIENTS, REPORTED WELLBEING 50 TO 150 MG OF THE BUTTERBUR ROOT EXTRACT DEPENDING ON AGE FOR A PERIOD OF 4 MONTHS. TREATMENT PROGRESSION WAS RECORDED IN MIGRAINE JOURNALS ESPECIALLY DESIGNED FOR CHILDREN AND ADOLESCENTS. RESULTS; 77% OF ALL PATIENTS REPORTED A REDUCTION 108 CHILDREN AND ADOLESCENTS BETWEEN AGES OF 6 AND 17 WERE INCLUDED IN A MULTICENTER PROSPECTIVE OPEN-LABEL STUDY. PARTICIPANTS SUFFERED FROM MIGRAINES DIAGNOSED ACCORDING TO IHS CLASSIFICATIONS FOR AT LEAST 1 YR. PATIENTS WERE TREATED WITH |
| Dose amount | 150.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN CHILD |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | CO2 EXTRACT |
| Gender | GIVEN TO BOTH SEXES |