| Disease | MEDIATORS.
PLACEBO COMPARED WITH OFI. THE SYMPTOMS OF THE ALCOHOL HANGOVER ARE LARGELY DUE TO ACTIVATION OF INFLAMMATION. AN EXTRACT OF OFI PLANT HAS A MODERATE EFFECT ON REDUCING HANGOVER SYMPTOMS, APPARENTLY BY INHIBITING THE PRODUCTION OF INFLAMMATORY
SEVERITY; THE MEAN SYMPTOM INDEX WAS 4.1 (95% CONFIDENCE INTERVAL,1.2-7.1;P=007) HIGHER IN SUBJECTS WITH MORNING C-REACTIVE PROTEIN LEVELS GREATER THAN 1.0 MG/L. IN ADDITION, C-REACTIVE PROTEIN LEVELS WERE 40% HIGHER AFTER SUBJECTS CONSUMED
(95% CONFIDENCE INTERVAL,-0.2 TO5.5; P=.07), AND THE RISK OF A SEVERE HANGOVER (>/=18 POINTS0 WAS REDUCED BY HALF (ODDS RATIO, 0.38; 95% CONFIDENCE INTERVAL,0.16-0.88; P=.02). C-REACTIVE PROTEIN LEVELS WERE STRONGLY ASSOCIATED WITH HANGOVER
PLACEBO REVERSED. 55 SUBJECTS COMPLETED BOTH THE OFI AND PLACEBO ARMS OF STUDY. THREE OF 9 SYMPTOMS-NAUSEA, DRY MOUTH, AND ANOREXIA-WERE SIGNIFICANTLY REDUCED BY OFI (ALL P<0.5). OVERALL, THE SYMPTOM INDEX WAS REDUCED BY 2.7 POINTS ON AVERAGE
1.75 G OF ALCOHOL/KG OF BODY WT. HANGOVER SEVERITY (9 SYMPTOMS) AND OVERALL WELL-BEING WERE ASSESSED ON A SCALE(0-6), AND BLOOD AND URINE SAMPLES WERE OBTAINED THE FOLLOWING MORNING. TWO WKS LATER, THE STUDY PROTOCOL WAS REPEATED WITH OFI AND
IN THIS DOUBLE-BLIND, PLACEBO-CONTROLLED, CROSSOVER TRIAL, 64 HEALTHY, YOUNG ADULT VOLUNTEERS WERE RANDOMLY ASSIGNED TO RECEIVE OFI (1600 IU) AND IDENTICAL PLACEBO, GIVEN 5 HRS BEFORE ALCOHOL CONSUMPTION. DURING 4 HRS, SUBJECTS CONSUMED UP TO |