Experiment 69652
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | MILLS,E: MONTORI,VM: WU,P: GALLICANO,K: CLARKE,M: GUYATT,G:. (2004). INTERACTION OF ST JOHN'S WORT WITH CONVENTIONAL DRUGS: SYSTEMIC REVIEW OF CLINICAL TRIALS.. 329() |
| Amount utilized | |
| Compound isolated | |
| Disease | BIOAVAILABILITY OF THE CONVENTIONAL DRUG; IN SEVEN STUDIES THE 95% CONFIDENCE INTERVAL EXCLUDED A DECREASE OF >20%. PARTICIPANTS OR INVESTIGATORS. IN 15 TRIALS, INVESTIGATORS INDEPENDENTLY ASSAYED THE HERB. OF 19 TRIALS WITH AVAILABLE PLASMA DATA, THREE FOUND NO IMPORTANT INTERACTION (CHANGE IN AREA UNDER THE CURVE>20%) AND 17 FOUND A DECREASE IN SYSTEMIC MOST(17) STUDIES USED A BEFORE AND AFTER DESIGN; FOUR STUDIES USED CONTROL GROUPS OTHER THAN THE ACTIVE GROUPS. THREE STUDIES RANDOMIZED THE SEQUENCE OF ADMINISTRATION OR THE PARTICIPANTS TO STUDY ARMS OR PERIODS; THREE STUDIES BLINDED CLINICAL TRIALS EVALUATING THE PHARMACOKINETIC EFFECT OF ST JOHN'S WORT ON THE METABOLISM OF CONVENTIONAL DRUGS. 22 PHARMACOKINETIC TRIALS STUDIED AN AVERAGE OF 12(SD5) PARTICIPANTS; 17 TRIALS STUDIED HEALTHY COLUNTEERS AND 5 STUDIED PATIENTS. TO DETERMINE THE METHODOLOGICAL QUALITY OF CLINICAL TRIALS THAT EXAMINED POSSIBLE INTERACTIONS OD ST JOHN'S WORT WITH CONVENTIONAL DRUGS, AND TO EXAMINE THE RESULTS OF THESE TRIALS. A SYSTEMIC REVIEW OF ELIGIBLE STUDIES, INCLUDING PROSPECTIVE |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |