Experiment 69659
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Crocus sativus (IRIDACEAE) |
| Citation | AKHONDZADEH,S: FALLAH-POUR,H: AFKHAM,K: JAMSHIDI,H: KHALIGHI-CIGAROUDI,F:. (2004). COMPARISON OF CROCUS SATIVUS L. AND IMIPRAMINE IN THE TREATMENT OF MILD TO MODERATE DEPRESSION: A PILOT DOUBLE-BLIND RANDOMIZED TRIAL.. 4(12) |
| Amount utilized | |
| Compound isolated | |
| Disease | FINDING FROM THE STUDY IS THAT SAFFRON MAY BE OF THERAPEUTIC BENEFIT IN THE TREATMENT OF MILD TO MODERATE DEPRESSION. TO THE BEST OF OUR KNOWLEDGE THIS IS THE FIRST CLINICAL TRIAL THAT SUPPORTS THIS INDICATION FOR SAFFRON. SIMILAR TO IMIPRAMINE IN THE TREATMENT OF MILD TO MODERATE DEPRESSION (F=2.91, D.F.=1, P=0.09). IN THE IMIPRAMINE GROUP ANTICHOLINGERIC EFFECTS SUCH AS DRY MOUTH AND ALSO SEDATION WERE OBSERVED MORE OFTEN THAT WAS PREDICTABLE. THE MAIN OVERALL DOUBLE-BLIND SINGLE-CENTER TRIAL, PATIENTS WERE RANDOMLY ASSIGNED TO RECEIVE CAPSULES OF SAFFRON 30 MG/DAY(TDS) (GROUP1) AND CAPSULE OF IMIPRAMINE 100 MG/DAY (TDS) (GROUP2) FOR A 6 WK STUDY. SAFFRON AT THIS DOSE WAS FOUND TO BE EFFECTIVE STATISTICAL MANUAL OF MENTAL DISORDERS, 4TH EDITION FOR MAJOR DEPRESSION BASED ON THE STRUCTURED CLINICAL INTERVIEW FOR DSM IV PARTICIPATED IN THE TRIAL. PATIENTS HAVE A BASELINE-HAMILTON RATING SCALE FOR DEPRESSION SCORE OF AT LEAST 18. IN THIS THE OBJECTIVE WAS TO COMPARE THE EFFICACY OF STIGMAS OF CROCUS SATIVUS (SAFFRON) WITH IMIPRAMINE IN THE TREATMENT OF MILD TO MODERATE DEPRESSION IN A 6 WK PILOT DOUBLE-BLIND RANDOMIZED TRIAL. 30 ADULT PATIENTS WHO MET THE DIAGNOSTIC AND |
| Dose amount | 30.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |