Experiment 69935

Worktypes

EFFECTS DUE TO A COMBINATION OF DRUGSANTICANCER AND/OR CYTOTOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN HUMANS

Compounds isolated

VINDESINE*

Alerts

A MIXTURE OF PURE COMPOUNDS WAS USED TO OBTAIN THE REPORTED EFFECT.DOSING ON DAY 1 ONLY.

Details

PropertyValue
Pharmacology
ANTITUMOR ACTIVITY
Administration routeIV
OrganismEmpty organism
CitationLE CHEVALLER,T: ARRIAGADA,R: BALDEYROU,P: MARTIN,M: DOUROUX,P: JACQUOTTE,A: SANCHO-GARNIER,H: ROUESSE,J:. (1985). COMBINED CHEMOTHERAPY (VINDESINE,LOMUSTINE,CISPLATIN,AND CYCLOPHOSPHAMIDE) AND RADICAL RADIOTHERAPY IN INOPERABLE NONMETASTATIC SQUAMOUS CELL CARCINOMA OF THE LUNG.. 69(5)
Amount utilized
Compound isolated
DiseaseIN THIS PHASE II STUDY OF 33 PATIENTS WITH ADVANCED SQUAMOUS CELL CARCINOMA OF THE LUNG, COMBINED CHEMOTHERAPY WITH VINDESINE, LOMUSTINE, CISPLATIN, CYCLOPHOSPHAMIDE AND RADICAL RADIOTHERAPY WERE USED. THERE WERE 18 FULL (54.5%) AND SIX PARTIAL (18%) RESPONSES. MEDIAN SURVIVAL WAS 15.9 MONTHS. 14 PATIENTS HAD NO TOXICITY, AND TWO HAD GRADE 4 HEMATOLOGICAL TOXICITY.
Dose amount1.5 MG
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitSQ M BODY SURFACE
Dose expressionDOSE