Experiment 70636
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | FIORE,JJ: KELSEN,DP: GRALLA,RJ: CASPER,ES: MAGILL,G: CHENG,E: OCHOA JR,M:. (1985). ADENOCARCINOMA OF UNKNOWN PRIMARY ORIGIN: TREATMENT WITH VINDESINE AND DOXORUBICIN.. 69(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | FORTY-TWO PATIENTS WITH ADENOCARCINOMA OF UNKNOWN PRIMARY ORIGIN WERE TREATED WITH COMBINATION CHENOTHERAPY OF ADRIAMYCIN (20 MG/SQ.M. IV) AND VINDESINE (3 MG/SG.M. IV) WEEKLY FOR 4 WEEKS AND EVERY TWO WEEKS THEREAFTER. OF 38 PATIENTS WITH EVALUABLE RESPONSE, ONE PATIENT WITH MEASURABLE DISEASE HAD A COMPLETE RESPONSE, FOUR WITH MEASURABLE DISEASE HAD PARTIAL RESPONSE, AND ONE WITH EVALUABLE DISEASE HAD MARKED IMPROVEMENT. HEMATOLOGICAL TOXICITY WAS MODERATE. THREE PATIENTS DEVELOPED LUEKOPENIA WHICH REQUIRED HOSPITALIZATION, AND TWO PATIENTS DEVELOPED THROMBOCYTOPENIA BUT HAD NO CLINICAL EVIDENCE OF BLEEDING. PERIPHERAL NEUROPATHY DUE TO VINDESINE WAS SEEN IN 11 PATIENTS AND REDUCTION OF DOSAGE WAS REQUIRED IN THREE. |
| Dose amount | 20.0 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |