Experiment 70638
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | FINN,GP: BOZEK,T: SOUHAMI,RL: SLEVIN,ML: THOMAS,DGT:. (1985). HIGH-DOSE ETOPOSIDE IN THE TREATMENT OF RELAPSED PRIMARY BRAIN TUMORS.. 69(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | TWENTY FOUR PATIENTS WITH RELAPSED PRIMARY BRAIN TUMORS WERE TREATED WITH HIGH DOSE ETOPOSIDE (600-1000 MG/SG.M.) DOSE WAS ADMINISTERED IN TWO SEPARATE INFUSIONS (RATE OF 1MG/MINUTE) GIVEN ON TWO CONSECUTIVE DAYS. TREATMENT WAS REPEATED AT THREE WEEK INTERVALS. ONE PATIENT SHOWED A PARTIAL RESPONSE AND THERE WERE FOUR CASES OF STABLE DISEASE. NINETEEN PATIENTS SHOWED DISEASE PROGRESSION BETWEEN ONE AND FOUR COURSES. NEUTROPENIA AND THROMBOCYTOPENIA WERE THE MAJOR SIDE EFFECTS, WITH ONLY ONE PATIENT REQUIRING IV ANTIBIOTICS DUE TO SEPTICEMIA. MILD TRANSIENT ABNORMALITIES WERE SEEN IN LIVER FUNCTION TESTS. OTHER TOXICITIES INCLUDE TRANSIENT ERYTHEMATOUS RASH, BLOOD CULTURE-NEGATIVE PYREXIA AND AN EPISODE OF HICCOUGHS. THERE WAS LITTLE NAUSEA AND VOMITING WERE MILD. PHARMAKOKINETIC PARAMETERS ARE GIVEN. |
| Dose amount | 600.0 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |