Experiment 70639
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | FINN,GP: BOZEK,T: SOUHAMI,RL: SLEVIN,ML: THOMAS,DGT:. (1985). HIGH-DOSE ETOPOSIDE IN THE TREATMENT OF RELAPSED PRIMARY BRAIN TUMORS.. 69(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | THREE PATIENTS WITH RELAPSED PRIMARY BRAIN TUMORS WERE TREATED WITH A TOTAL DOSE OF 1 G/SG.M GIVEN ON TWO CONSECUTIVE DAYS IN DIVIDED DOSES OF 500 MG/SQ.M. EACH DOSE WAS INFUSED AT A RATE OF 1 MG/MINUTE. PLATEAU CONCENTRATIONS WERE 12.3, 21.2 AND 34.5 UG/ML ON DAY 1, AND 12.7, 27.4 AND 35.3 UG/ML ON DAY 2 IN THE 3 PATIENTS. THE AREA UNDER THE CURVE FOR THE THREE PATIENTS WERE 282, 375, AND 602 UG/ML HOURS ON DAY 1 AND 314, 378 AND 637 UG/ML HOURS ON DAY 2. THE SINGLE CSF CONCENTRATION OF ETOPOSIDE WAS 0.57 UG/ML, 3.9% OF THE SIMULTANEOUS PLASMA CONCENTRATION. |
| Dose amount | 1.0 GM |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |