Experiment 70640
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | YOUNG,JA: WESTLAKE,D: SCHNETZER III,GW: KELLER,AM: SEXAUER,JM: NEWCOMER,LN:. (1985). PHASE I STUDY OF DIVIDED-DOSE VINBLASTINE IN ADVANCED MALIGNANCY.. 69(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE I STUDY,31 PATIENTS WITH ADVANCED MALIGNANCY WERE TREATED BY IV BOLUS AT O AND 48 HOURS OF A 21 DAY CYCLE. PATIENTS AVERAGED 2.7 CYCLES.THERE WAS ONE COMPL ETE RESPONSE IN METASTATIC OVARIAN CANCER AND ONE IN METASTATIC BREAST CANCER. 5 PATIENTS HAD NEUTROPENIA,BUT THERE WAS NO SIGNIFICANT THROMBOCYTOPENIA.OTHER TOXICITIES INCLUDE FILEUS,CONSTIPATION (5 PATIENTS) AND ONE CASE OF SUPERFICIAL PHLEBITIS OF THE PERIPHERAL VEIN.SERUM LEVELS WERE SIMILAR TO THOSE SEEN IN 5 DAY INFUSION. |
| Dose amount | 3=3.0 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |