Experiment 72198
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | MAITI,M: NANDI,R: CHAUDHURI,K:. (1984). INTERACTION OF SANGUINARINE WITH NATURAL AND SYNTHETIC DEOXYRIBONUCLEIC ACIDS.. 21(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | INTERACTION OF SANGUINARINE WITH DNA WAS STUDIED USING ABSORPTION AND FLUORESCENCE SPECTROPHOTOMETRY, VISCOMETRY AND CIRCULAR DICHROISM. ABSORPTION SPECTRUM OF DNA UNDERWENT BATHOCHROMIC AND HYPOCHROMIC SHIFT, FLUORESCENCE WAS QUENCHED, INDICATING A STRONG INTERACTION DEPENDING ON DNA BASE COMPOSITION. THE VISCOSITY OF SONICATED ROD-LIKE DNA FRAGMENTS WAS INCREASED AND AN ETHIDIUM BROMIDE-LIKE UNWINDING PROCESS OF COVALENTLY CLOSED SUPERHELICAL DNA WAS INDUCED. CIRCULAR DICHROISM MEASUREMENTS SHOWED THAT CONFORMATIONAL CHANGES WERE INDUCED. |
| Dose amount | 36.0 MICROMOLS |
| Number | 1 |
| Qualitative result | ACTIVE |
| Dose expression | CONC USED |