Experiment 73424
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | MC GOVREN,JP: PRATT,EA: BELT,RJ: TAYLOR,SA: BENJAMIN,RS: ARDALAN,B: OHNUMA,T:. (1985). PHARMACOKINETIC AND BIOCHEMICAL STUDIES ON ACIVICIN IN PHASE I CLINICAL TRIALS.. 45(9) |
| Amount utilized | |
| Compound isolated | |
| Disease | PHARMACOKINETICS WAS MEASURED IN PATIENTS AS PART OF A PHASE I CLINICAL TRIAL. 8 PATIENTS RECEIVED A SINGLE DOSE COURSE OF 40,60,100 OR 150MG/SQ.M. 4 PATIENTS WERE TREATED ON A 5 DAY COURSE AT 5.4 OR 8.5MG/SQ.M/DAY.COURSE REPEATED EVERY 3 WEEKS A BIEXPONENTIAL PATTERN WAS SEEN WITH A TERMINAL HALF LIFE OF 9.92 H AND A DISTRIBUTION PHASE HALF LIFE OF 0.32 H. TOTAL BODY CLEARANCE WAS 1.69 LITTERS/H/SQ.M.AND VOLUME OF DISTRIBUTION 21.79 LITERS/SQ.M. THE KINETICS APPEAR TO BE DOSE DEPENDENT OVER A DOSAGE RANGE OF 8.5 - 150MG/SQ.M./DAY. URINARY EXCRETION OF UNCHANGED DRUG RANGES FROM 2-42% DURING THE FIRST 24 HOURS FOLLOWING ADMINISTRATION. |
| Dose amount | VAR |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |