Experiment 7463
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | SC |
| Organism | Empty organism |
| Citation | MASTRANGELO,MJ: GRAGE,TB: BELLET,RE: WEISS,AJ:. (1973). A PHASE I STUDY OF EMETINE HYDROCHLORIDE (NSC 33669) IN SOLID TUMORS.. 31() |
| Amount utilized | |
| Compound isolated | |
| Disease | PHASE I CLINICAL TRIAL IN ADULTS WITH SOLID TUMORS.DOSING EVERY4 DAYS IN 9 PATIENTS TOXICITY CONSISTED OF PAIN AT INJECTION SITE,MUSCLE WEAKNESS(DOSE-LIMITING),MYALGIA,ELEVATED CREATINE PHOSPHOKINASE AND ELECTROCARDIOGRAPHIC ABNORMALITIES MAXIMUM TOLERABLE TOTAL DOSE WAS 10.0 MG/KG |
| Dose amount | 1.2 MG |
| Number | 3 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | KG |
| Dose expression | DOSE |